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Abstract
A 45-year-old woman presented with recent onset of left-sided chest pain. On clinical examination, these symptoms seemed to be strictly localized to a region that was marked by a long-standing cutaneous erythematous lesion. Laboratory results showed no gross abnormalities. Radiological imaging including conventional X-ray, MRI scans, and 3D CT reconstruction of the rib cage revealed circumscript destruction of the left lateral ribs 9-11. Histological analysis of a rib biopsy showed angiomatous hypervascularization and intracortical fibrosis. In keeping with these findings, the patient's condition was diagnosed as Gorham-Stout disease, a rare condition with localized, often unilateral, bone destruction. Monotherapy with bisphosphonates (pamidronate 30 mg i.v. every 3 months) was initiated, leading to rapid disappearance of local pain. Follow-up over 24 months documented a stable clinical and radiological picture without evidence of progressive bone destruction.
Original language | English |
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Pages (from-to) | 350-353 |
Number of pages | 4 |
Journal | Journal of Bone and Mineral Research |
Volume | 20 |
DOIs | |
Publication status | Published - 1 Feb 2005 |
Keywords
- vanishing bone disease
- RANKL
- local osteolysis
- pamidronate
- interleukin-6
- osteoprotegerin
- Gorham-Stout disease
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Dive into the research topics of 'Gorham Stout disease - stabilization during bisphosphonate treatment'. Together they form a unique fingerprint.Projects
- 1 Finished
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Pre-Receptor Regulation of Dehydroepiandrosterone Synthesis, Metabolism and Action
Arlt, W. (Principal Investigator)
1/08/04 → 31/10/09
Project: Research Councils