Gold-silica quantum rattles for multimodal imaging and therapy

Mathew Hembury; Ciro Chiappini; Sergio Bertazzo; Tammy Kalber; Glenna L Drisko; Olumide Ogunlade; Simon Walker-Samuel; Katla Sai Krishna; Coline Jumeaux; Paul Beard; Challa S S R Kumar; Alexandra E Porter; Mark Lythgoe; Cedric Boissiere; Clement Sanchez; Molly M Stevens

doi:10.1073/pnas.1419622112

Gold-silica quantum rattles for multimodal imaging and therapy

Mathew Hembury, Ciro Chiappini, Sergio Bertazzo, Tammy Kalber, Glenna L Drisko, Olumide Ogunlade, Simon Walker-Samuel, Katla Sai Krishna, Coline Jumeaux, Paul Beard, Challa S S R Kumar, Alexandra E Porter, Mark Lythgoe, Cedric Boissiere, Clement Sanchez, Molly M Stevens

Cardiovascular Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Therapeutic and diagnostic nanoparticles combine multiple functionalities to improve efficacy of treatment but often require assembling complex systems at the expense of overall performance. Here we present a simple strategy to synthesize a hybrid, rattle-like, gold–silica nanoparticle that very efficiently combines therapy and imaging in an animal model. The nanoparticle design is uniquely centered on enabling the use of gold quantum dots (

Original language	English
Pages (from-to)	1959-1964
Journal	Proceedings of the National Academy of Sciences
Volume	7
DOIs	https://doi.org/10.1073/pnas.1419622112
Publication status	Published - 17 Feb 2015

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Hembury, M., Chiappini, C., Bertazzo, S., Kalber, T., Drisko, G. L., Ogunlade, O., Walker-Samuel, S., Krishna, K. S., Jumeaux, C., Beard, P., Kumar, C. S. S. R., Porter, A. E., Lythgoe, M., Boissiere, C., Sanchez, C., & Stevens, M. M. (2015). Gold-silica quantum rattles for multimodal imaging and therapy. Proceedings of the National Academy of Sciences, 7, 1959-1964. https://doi.org/10.1073/pnas.1419622112

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abstract = "Therapeutic and diagnostic nanoparticles combine multiple functionalities to improve efficacy of treatment but often require assembling complex systems at the expense of overall performance. Here we present a simple strategy to synthesize a hybrid, rattle-like, gold–silica nanoparticle that very efficiently combines therapy and imaging in an animal model. The nanoparticle design is uniquely centered on enabling the use of gold quantum dots (",

author = "Mathew Hembury and Ciro Chiappini and Sergio Bertazzo and Tammy Kalber and Drisko, {Glenna L} and Olumide Ogunlade and Simon Walker-Samuel and Krishna, {Katla Sai} and Coline Jumeaux and Paul Beard and Kumar, {Challa S S R} and Porter, {Alexandra E} and Mark Lythgoe and Cedric Boissiere and Clement Sanchez and Stevens, {Molly M}",

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doi = "10.1073/pnas.1419622112",

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Hembury, M, Chiappini, C, Bertazzo, S, Kalber, T, Drisko, GL, Ogunlade, O, Walker-Samuel, S, Krishna, KS, Jumeaux, C, Beard, P, Kumar, CSSR, Porter, AE, Lythgoe, M, Boissiere, C, Sanchez, C & Stevens, MM 2015, 'Gold-silica quantum rattles for multimodal imaging and therapy', Proceedings of the National Academy of Sciences, vol. 7, pp. 1959-1964. https://doi.org/10.1073/pnas.1419622112

TY - JOUR

T1 - Gold-silica quantum rattles for multimodal imaging and therapy

AU - Hembury, Mathew

AU - Chiappini, Ciro

AU - Bertazzo, Sergio

AU - Kalber, Tammy

AU - Drisko, Glenna L

AU - Ogunlade, Olumide

AU - Walker-Samuel, Simon

AU - Krishna, Katla Sai

AU - Jumeaux, Coline

AU - Beard, Paul

AU - Kumar, Challa S S R

AU - Porter, Alexandra E

AU - Lythgoe, Mark

AU - Boissiere, Cedric

AU - Sanchez, Clement

AU - Stevens, Molly M

PY - 2015/2/17

Y1 - 2015/2/17

N2 - Therapeutic and diagnostic nanoparticles combine multiple functionalities to improve efficacy of treatment but often require assembling complex systems at the expense of overall performance. Here we present a simple strategy to synthesize a hybrid, rattle-like, gold–silica nanoparticle that very efficiently combines therapy and imaging in an animal model. The nanoparticle design is uniquely centered on enabling the use of gold quantum dots (

AB - Therapeutic and diagnostic nanoparticles combine multiple functionalities to improve efficacy of treatment but often require assembling complex systems at the expense of overall performance. Here we present a simple strategy to synthesize a hybrid, rattle-like, gold–silica nanoparticle that very efficiently combines therapy and imaging in an animal model. The nanoparticle design is uniquely centered on enabling the use of gold quantum dots (

U2 - 10.1073/pnas.1419622112

DO - 10.1073/pnas.1419622112

M3 - Article

C2 - PMC4343080

SN - 1091-6490

VL - 7

SP - 1959

EP - 1964

JO - Proceedings of the National Academy of Sciences

JF - Proceedings of the National Academy of Sciences

ER -

Gold-silica quantum rattles for multimodal imaging and therapy

Abstract

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