Abstract
Dengue and chikungunya virus are important arboviruses of public health concern. In the past decades, they have accounted for numerous outbreaks of dengue and chikungunya in different parts of the world. Several cases of concurrent infection of dengue and chikungunya have been documented. However, the true burden of this concurrent infection is unknown. Here, a systematic review and meta-analysis of published data on the prevalence of dengue and chikungunya coinfection in the human population was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. Six electronic databases (Web of science, Embase, PubMed, ScienceDirect, Scopus, and Google Scholar) were searched without year or language restrictions for relevant studies. The study protocol was registered with PROSPERO (CRD42020175344). Eighty-three studies involving a total of 43,341 participants were included. The random-effects model was employed to calculate the summary estimates. A pooled global prevalence of 2.5% (95% CI: 1.8–3.4) was obtained for dengue and chikungunya coinfection. Males and females appear to be coinfected at a fairly similar rate. Among the regions, Asia accounted for the highest prevalence (3.3%, 95% CI: 2.3–4.6) while North America was the least (0.8%, 95% CI: 0.3–2.4). The prevalence estimates varied across different countries. A much higher prevalence rates were obtained for Colombia (37.4%, 95% CI: 9.1–78.1), Madagascar (18.2%, 95% CI: 10.1–30.6), Laos (12.5%, 95% CI: 5.3–26.7), Maldives (4.5%, 95% CI: 1.5–13.0) and Thailand (3.7%, 95% CI: 0.4–26.3). This first extensive systematic review and meta-analysis reveals dengue and chikungunya coinfection as a global problem worthy of consideration. It is therefore pertinent that both infections be assessed during diagnosis, mosquito vector control practices be implemented, and vaccine development strides be supported globally.
Original language | English |
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Article number | 106408 |
Number of pages | 15 |
Journal | Acta Tropica |
Volume | 231 |
Early online date | 16 Mar 2022 |
DOIs | |
Publication status | Published - Jul 2022 |
Bibliographical note
Funding Information:We would like to thank the Hamdan Tahir Library, Universiti Sains Malaysia, for helping to access some of the articles used in this work. Irekeola A.A. and Engku Nur Syafirah E.A.R. are supported by Universiti Sains Malaysia via the USM Fellowship Scheme.
This research was funded by the Malaysian Ministry of Higher Education through the Fundamental Research Grant Scheme [FRGS/1/2021/SKK06/USM/02/2] and by grants from Universiti Sains Malaysia (304.PPSP.6316338 and 304.PPSP.6316148). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2022
Keywords
- Burden
- Chikungunya
- Coinfection
- Dengue
- Prevalence
ASJC Scopus subject areas
- Parasitology
- veterinary (miscalleneous)
- Insect Science
- Infectious Diseases