Genomic epidemiology of human adenovirus F40 and F41 in coastal Kenya: A retrospective hospital-based surveillance study (2013–2022)

Arnold W Lambisia; Timothy O Makori; Martin Mutunga; Robinson Cheruiyot; Nickson Murunga; Joshua Quick; George Githinji; D James Nokes; Charlotte J Houldcroft; Charles N Agoti

doi:10.1093/ve/vead023

Genomic epidemiology of human adenovirus F40 and F41 in coastal Kenya: A retrospective hospital-based surveillance study (2013–2022)

Arnold W Lambisia^*, Timothy O Makori, Martin Mutunga, Robinson Cheruiyot, Nickson Murunga, Joshua Quick, George Githinji, D James Nokes, Charlotte J Houldcroft, Charles N Agoti

^*Corresponding author for this work

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Abstract

Human enteric adenovirus species F (HAdV-F) is a leading cause of childhood diarrhoeal deaths. The genomic analysis would be key to understanding transmission dynamics, potential drivers of disease severity, and vaccine development. However, currently, there are limited HAdV-F genomic data globally. Here, we sequenced and analysed HAdV-F from stool samples collected in coastal Kenya between 2013 and 2022. The samples were collected at Kilifi County Hospital in coastal Kenya from children

Original language	English
Article number	vead023
Journal	Virus evolution
Volume	9
Issue number	1
DOIs	https://doi.org/10.1093/ve/vead023
Publication status	Published - 24 Mar 2023

Bibliographical note

Funding
This study was funded by The Wellcome Trust [102975 and 203077]. C.N.A. was supported by the Initiative to Develop African Research Leaders (IDeAL) through the DELTAS Africa Initiative [DEL-407 15-003]. The DELTAS Africa Initiative is an independent funding scheme of the African Academy of Sciences (AAS)’s Alliance for Accelerating Excellence in Science in Africa and is supported by the New Partnership for Africa’s Development Planning and Coordinating Agency (NEPAD Agency). C.J.H. was supported by funding from the Department of Genetics, University of Cambridge. J.Q. was supported by funding from the UK Research and Innovation body. The views expressed in this report are those of the authors and not necessarily those of the AAS, the NEPAD Agency, the Wellcome, the UK Research and Innovation (UKRI), the University of Cambridge, and the UK government.

Keywords

F40/41
human adenovirus F
recombination
Kenya

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Genomic epidemiology of human adenovirus F40 and F41 in coastal Kenya: A retrospective hospital-based surveillance study (2013–2022)",

abstract = "Human enteric adenovirus species F (HAdV-F) is a leading cause of childhood diarrhoeal deaths. The genomic analysis would be key to understanding transmission dynamics, potential drivers of disease severity, and vaccine development. However, currently, there are limited HAdV-F genomic data globally. Here, we sequenced and analysed HAdV-F from stool samples collected in coastal Kenya between 2013 and 2022. The samples were collected at Kilifi County Hospital in coastal Kenya from children",

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note = "Funding This study was funded by The Wellcome Trust [102975 and 203077]. C.N.A. was supported by the Initiative to Develop African Research Leaders (IDeAL) through the DELTAS Africa Initiative [DEL-407 15-003]. The DELTAS Africa Initiative is an independent funding scheme of the African Academy of Sciences (AAS){\textquoteright}s Alliance for Accelerating Excellence in Science in Africa and is supported by the New Partnership for Africa{\textquoteright}s Development Planning and Coordinating Agency (NEPAD Agency). C.J.H. was supported by funding from the Department of Genetics, University of Cambridge. J.Q. was supported by funding from the UK Research and Innovation body. The views expressed in this report are those of the authors and not necessarily those of the AAS, the NEPAD Agency, the Wellcome, the UK Research and Innovation (UKRI), the University of Cambridge, and the UK government.",

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AU - Cheruiyot, Robinson

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AU - Quick, Joshua

AU - Githinji, George

AU - Nokes, D James

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AB - Human enteric adenovirus species F (HAdV-F) is a leading cause of childhood diarrhoeal deaths. The genomic analysis would be key to understanding transmission dynamics, potential drivers of disease severity, and vaccine development. However, currently, there are limited HAdV-F genomic data globally. Here, we sequenced and analysed HAdV-F from stool samples collected in coastal Kenya between 2013 and 2022. The samples were collected at Kilifi County Hospital in coastal Kenya from children

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Genomic epidemiology of human adenovirus F40 and F41 in coastal Kenya: A retrospective hospital-based surveillance study (2013–2022)

Abstract

Bibliographical note

Keywords

UN SDGs

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