Genetic control of plant development by overriding a geometric division rule

Saiko Yoshida, Pierre Barbier de Reuille, Brendan Lane, George W Bassel, Przemyslaw Prusinkiewicz, Richard S Smith, Dolf Weijers

Research output: Contribution to journalArticlepeer-review

130 Citations (Scopus)


Formative cell divisions are critical for multicellular patterning. In the early plant embryo, such divisions follow from orienting the division plane. A major unanswered question is how division plane orientation is genetically controlled, and in particular whether this relates to cell geometry. We have generated a complete 4D map of early Arabidopsis embryogenesis and used computational analysis to demonstrate that several divisions follow a rule that uses the smallest wall area going through the center of the cell. In other cases, however, cell division clearly deviates from this rule, which invariably leads to asymmetric cell division. By analyzing mutant embryos and through targeted genetic perturbation, we show that response to the hormone auxin triggers a deviation from the "shortest wall" rule. Our work demonstrates that a simple default rule couples division orientation to cell geometry in the embryo and that genetic regulation can create patterns by overriding the default rule.

Original languageEnglish
Pages (from-to)75-87
Number of pages13
JournalDevelopmental Cell
Issue number1
Publication statusPublished - 14 Apr 2014

Bibliographical note

Copyright © 2014 Elsevier Inc. All rights reserved.


  • Arabidopsis
  • Asymmetric Cell Division
  • Cell Differentiation
  • Germination
  • Models, Biological
  • Organogenesis, Plant
  • Plant Cells
  • Plant Development


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