Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells

JR Mora, Johannes Eksteen, M Iwata, S-Y Song, T Junt, B Senman, KL Otipoby, A Yokota, H Takeuchi, P Ricciardi-Castagnoli, K Rajewski, David Adams, UH Von Andrian

Research output: Contribution to journalArticle

720 Citations (Scopus)


Normal intestinal mucosa contains abundant immunoglobulin A (IgA)-secreting cells, which are generated from B cells in gut-associated lymphoid tissues (GALT). We show that dendritic cells (DC) from GALT induce T cell-independent expression of IgA and gut-homing receptors on B cells. GALT-DC-derived retinoic acid (RA) alone conferred gut tropism but could not promote IgA secretion. However, RA potently synergized with GALT-DC-derived interleukin-6 (IL-6) or IL-5 to induce IgA secretion. Consequently, mice deficient in the RA precursor vitamin A lacked IgA-secreting cells in the small intestine. Thus, GALT-DC shape mucosal immunity by modulating B cell migration and effector activity through synergistically acting mediators.
Original languageEnglish
Pages (from-to)1157-60
Number of pages4
Publication statusPublished - 17 Nov 2006


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