While the major application of gels has historically been as delivery systems for small molecule and protein/peptide drugs, the benefits of gels as delivery vehicles are being increasingly translated to the field of subunit vaccine delivery. This chapter will present a summary of gel systems commonly employed to date in the delivery of subunit antigens, categorised according to mechanism of gelation and principal gelling component. Examples of preclinical and also clinical studies in which gels have been employed as delivery systems for vaccines will be given. Gels as bulk delivery systems will be focused on in this chapter; however, the reader’s attention is also drawn to the increasingly popular application of nanogels (nanosized polymeric gels) as vaccine delivery systems.
|Title of host publication||Subunit Vaccine Delivery |
|Publisher||Springer Science + Business Media|
|Publication status||Published - 2015|
|Name||Advances in Delivery Science and Technology|