Gadolinium Doped Layered Double Hydroxides for Simultaneous Drug Delivery and Magnetic Resonance Imaging

Ziwei Zhang; Connor J.R. Wells; Ruizheng Liang; Gemma Louise Davies; Gareth R. Williams

doi:10.1007/s10876-022-02226-5

Gadolinium Doped Layered Double Hydroxides for Simultaneous Drug Delivery and Magnetic Resonance Imaging

Ziwei Zhang, Connor J.R. Wells, Ruizheng Liang, Gemma Louise Davies^*, Gareth R. Williams^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

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Abstract

In this study, gadolinium (Gd) doped MgAl layered double hydroxides (LDHs) were synthesized via a ‘bottom-up’ method and fully characterized by X-ray diffraction, infrared spectroscopy and relaxivity measurements. Two cytotoxic agents were then intercalated via ion-exchange. X-ray diffraction patterns exhibit expanded interlayer spacings as a result of successful drug intercalation. Infrared spectra also showed characteristic peaks of the incorporated methotrexate (MTX) or 5-fluorouracil (5-FU). The LDHs were found to be highly stable under physiological conditions, while in acidic conditions a small proportion of Gd was freed into the immersion medium. Dissolution tests revealed that both 5FU and MTX were rapidly released from the LDH carrier. The longitudinal relaxivity of Gd-LDHs remains largely stable during drug release over 24 h, and was higher in acidic environments. Overall, the drug-loaded Gd-LDH systems prepared in this study could serve as pH-sensitive theranostic platforms for MRI-guided anti-cancer therapy.

Original language	English
Pages (from-to)	385-394
Number of pages	10
Journal	Journal of Cluster Science
Volume	34
Issue number	1
Early online date	3 Feb 2022
DOIs	https://doi.org/10.1007/s10876-022-02226-5
Publication status	Published - Jan 2023

Bibliographical note

Funding Information:
The authors gratefully thank Dr Andrew Weston for assistance with electron microscopy experiments.

Publisher Copyright:
© 2022, The Author(s).

Keywords

Drug delivery
Layered double hydroxide
Magnetic resonance imaging
Theranostics

ASJC Scopus subject areas

General Chemistry
Biochemistry
General Materials Science
Condensed Matter Physics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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ZhangZ2022GadoliniumFinal published version, 1.47 MBLicence: Creative Commons: Attribution (CC BY)

Cite this

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title = "Gadolinium Doped Layered Double Hydroxides for Simultaneous Drug Delivery and Magnetic Resonance Imaging",

abstract = "In this study, gadolinium (Gd) doped MgAl layered double hydroxides (LDHs) were synthesized via a {\textquoteleft}bottom-up{\textquoteright} method and fully characterized by X-ray diffraction, infrared spectroscopy and relaxivity measurements. Two cytotoxic agents were then intercalated via ion-exchange. X-ray diffraction patterns exhibit expanded interlayer spacings as a result of successful drug intercalation. Infrared spectra also showed characteristic peaks of the incorporated methotrexate (MTX) or 5-fluorouracil (5-FU). The LDHs were found to be highly stable under physiological conditions, while in acidic conditions a small proportion of Gd was freed into the immersion medium. Dissolution tests revealed that both 5FU and MTX were rapidly released from the LDH carrier. The longitudinal relaxivity of Gd-LDHs remains largely stable during drug release over 24 h, and was higher in acidic environments. Overall, the drug-loaded Gd-LDH systems prepared in this study could serve as pH-sensitive theranostic platforms for MRI-guided anti-cancer therapy.",

keywords = "Drug delivery, Layered double hydroxide, Magnetic resonance imaging, Theranostics",

author = "Ziwei Zhang and Wells, {Connor J.R.} and Ruizheng Liang and Davies, {Gemma Louise} and Williams, {Gareth R.}",

note = "Funding Information: The authors gratefully thank Dr Andrew Weston for assistance with electron microscopy experiments. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2023",

month = jan,

doi = "10.1007/s10876-022-02226-5",

language = "English",

volume = "34",

pages = "385--394",

journal = "Journal of Cluster Science",

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T1 - Gadolinium Doped Layered Double Hydroxides for Simultaneous Drug Delivery and Magnetic Resonance Imaging

AU - Zhang, Ziwei

AU - Wells, Connor J.R.

AU - Liang, Ruizheng

AU - Davies, Gemma Louise

AU - Williams, Gareth R.

PY - 2023/1

Y1 - 2023/1

N2 - In this study, gadolinium (Gd) doped MgAl layered double hydroxides (LDHs) were synthesized via a ‘bottom-up’ method and fully characterized by X-ray diffraction, infrared spectroscopy and relaxivity measurements. Two cytotoxic agents were then intercalated via ion-exchange. X-ray diffraction patterns exhibit expanded interlayer spacings as a result of successful drug intercalation. Infrared spectra also showed characteristic peaks of the incorporated methotrexate (MTX) or 5-fluorouracil (5-FU). The LDHs were found to be highly stable under physiological conditions, while in acidic conditions a small proportion of Gd was freed into the immersion medium. Dissolution tests revealed that both 5FU and MTX were rapidly released from the LDH carrier. The longitudinal relaxivity of Gd-LDHs remains largely stable during drug release over 24 h, and was higher in acidic environments. Overall, the drug-loaded Gd-LDH systems prepared in this study could serve as pH-sensitive theranostic platforms for MRI-guided anti-cancer therapy.

AB - In this study, gadolinium (Gd) doped MgAl layered double hydroxides (LDHs) were synthesized via a ‘bottom-up’ method and fully characterized by X-ray diffraction, infrared spectroscopy and relaxivity measurements. Two cytotoxic agents were then intercalated via ion-exchange. X-ray diffraction patterns exhibit expanded interlayer spacings as a result of successful drug intercalation. Infrared spectra also showed characteristic peaks of the incorporated methotrexate (MTX) or 5-fluorouracil (5-FU). The LDHs were found to be highly stable under physiological conditions, while in acidic conditions a small proportion of Gd was freed into the immersion medium. Dissolution tests revealed that both 5FU and MTX were rapidly released from the LDH carrier. The longitudinal relaxivity of Gd-LDHs remains largely stable during drug release over 24 h, and was higher in acidic environments. Overall, the drug-loaded Gd-LDH systems prepared in this study could serve as pH-sensitive theranostic platforms for MRI-guided anti-cancer therapy.

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KW - Theranostics

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DO - 10.1007/s10876-022-02226-5

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SP - 385

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JO - Journal of Cluster Science

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IS - 1

ER -

Gadolinium Doped Layered Double Hydroxides for Simultaneous Drug Delivery and Magnetic Resonance Imaging

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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