Factors predisposing women to chronic pelvic pain: systematic review

PM Latthe, Luciano Mignini, Richard Gray, Robert Hills, Khalid Khan

Research output: Contribution to journalArticle

333 Citations (Scopus)


Objective To evaluate factors predisposing women to chronic and recurrent pelvic pain. Design, data sources, and methods Systematic review Of relevant studies without language restrictions identified through Medline, Embase, PsycINFO, Cochrane Library, SCISEARCH, conference papers, and bibliographies of retrieved primary and review articles. Two reviewers independently extracted clam Oil study characteristics, quality and results.. Exposure to risk factors was compared between women with and without pelvic pain. Results were pooled within subgroups defined by type of pain and risk factors. Results There were 122 studies (in 111 articles) of which 63 (in 64 286 women) evaluated 54 risk factors for dysmenorrhoea, 19 (in 18 601 women) evaluated 14 risk factors for dyspareunia, and 40 (in 12 040 women) evaluated 48 factors for non-cyclical pelvic pain. Age <30 years, low body mass index, smoking, earlier menarche (<12 years), longer cycles, heavy menstrual flow, nullliparity, premenstrual syndrome, sterilisation, clinically suspected pelvic inflammatory disease, sexual abuse, and psychological symptoms were associated with dysmenorrhoea. Younger age at first childbirth, exercise, and oral contraceptives were negatively associated with dysmenorrhoea. Menopause, pelvic inflammatory disease, sexual abuse, anxiety, and depression were associated with dyspareunia. Drug Or alcohol abuse, miscarriage, heavy menstrual flow, pelvic inflammatory disease, previous caesarean section, pelvic pathology, abuse, and psychological comorbidity were associated with all increased risk of non-cyclical pelvic pain. Conclusion Several gynaecological and psychosocial factors are strongly associated with chronic pelvic pain. Randomised controlled trials of interventions targeting these potentially modifiable factors are needed to assess their clinical relevance in chronic pelvic pain.
Original languageEnglish
Pages (from-to)749-755
Number of pages7
JournalBritish Medical Journal
Publication statusPublished - 1 Apr 2006


Dive into the research topics of 'Factors predisposing women to chronic pelvic pain: systematic review'. Together they form a unique fingerprint.

Cite this