TY - JOUR
T1 - Evolution of bacterial transcription factors
T2 - how proteins take on new tasks, but do not always stop doing the old ones
AU - Visweswariah, Sandhya S
AU - Busby, Stephen J W
N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.
PY - 2015/5/20
Y1 - 2015/5/20
N2 - Many bacterial transcription factors do not behave as per the textbook operon model. We draw on whole genome work, as well as reported diversity across different bacteria, to argue that transcription factors may have evolved from nucleoid-associated proteins. This view would explain a large amount of recent data gleaned from high-throughput sequencing and bioinformatic analyses.
AB - Many bacterial transcription factors do not behave as per the textbook operon model. We draw on whole genome work, as well as reported diversity across different bacteria, to argue that transcription factors may have evolved from nucleoid-associated proteins. This view would explain a large amount of recent data gleaned from high-throughput sequencing and bioinformatic analyses.
U2 - 10.1016/j.tim.2015.04.009
DO - 10.1016/j.tim.2015.04.009
M3 - Article
C2 - 26003748
SN - 0966-842X
JO - Trends in Microbiology
JF - Trends in Microbiology
ER -