Evaluation of the role of sex as a prognostic factor in critically ill adults with sepsis: Systematic review protocol

Jesus Lopez-Alcalde; Alba Antequera Martín; Elena Stallings; Alfonso Muriel; Borja Fernández-Félix; Ivan Solà; Rosa Del Campo; Manuel Ponce-Alonso; Federico Gordo; Pilar Fidalgo; Ana Verónica Halperin; Noelia Álvarez-Díaz; Olaya Madrid-Pascual; Gerard Urrutia; Javier Zamora

doi:10.1136/bmjopen-2019-035927

Evaluation of the role of sex as a prognostic factor in critically ill adults with sepsis: Systematic review protocol

Jesus Lopez-Alcalde, Alba Antequera Martín^*, Elena Stallings, Alfonso Muriel, Borja Fernández-Félix, Ivan Solà, Rosa Del Campo, Manuel Ponce-Alonso, Federico Gordo, Pilar Fidalgo, Ana Verónica Halperin, Noelia Álvarez-Díaz, Olaya Madrid-Pascual, Gerard Urrutia, Javier Zamora

^*Corresponding author for this work

Metabolism and Systems Research

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Introduction Sepsis is a leading cause of mortality in critically ill patients. Recently, it has been recognised that sex may contribute to a differential risk for developing sepsis and it remains uncertain if the prognosis of sepsis varies between the sexes. The aim of this systematic review is to summarise the available evidence to assess the role of sex as a prognostic factor in patients with sepsis managed in the intensive care unit (ICU). Methods and analysis This is a systematic review protocol of prognostic studies of sex in patients with sepsis managed in the ICU. The primary outcomes include all-cause hospital mortality and all-cause hospital mortality during the first 28 days. The secondary outcomes include all-cause hospital mortality during the first 7 days and all-cause mortality at 1 year. We will conduct a search strategy based on the population (sepsis), the prognostic factor (sex), the outcome of interest (mortality) and prognostic study methods. We will search in the following databases up to December 2019: MEDLINE Ovid (from 1976), Embase Elsevier (from 1974), Web of Science and two trial registries. We will impose no language restrictions. Two authors will independently screen titles, abstracts and full-text articles for eligibility of studies, and subsequently extract data. Two authors will independently assess the risk of bias of each study using the Quality in Prognostic Studies (QUIPS) tool. If possible, we will carry out a meta-analysis to provide a pooled prognostic effect estimate for each outcome. We will use the Grading of Recommendations Assessment, Development and Evaluation system to assess the quality of evidence. Ethics and dissemination Ethical approval will not be required. Findings from this review will be reported in a peer-reviewed scientific journal. Additionally, the results will be disseminated at conferences and in the mass media. PROSPERO registration number CRD42019145054.

Original language	English
Article number	e035927
Journal	BMJ open
Volume	10
Issue number	5
DOIs	https://doi.org/10.1136/bmjopen-2019-035927
Publication status	Published - 6 May 2020

Bibliographical note

Funding Information:
Funding The SEXCOMPLEX project was supported by Instituto de Salud Carlos III (Plan Estatal de I + D + i 2013–2016) and co-financed by the European Development Regional Fund 'A way to achieve Europe' (ERDF) grant number PIE16/00050. AAM was funded by the Instituto de Salud Carlos III through the “AcciónEstratégica en Salud 2013–2016 / Contratos Río Hortega call 2018/ CM18/00141” (Co-funded by European Social Fund 2014–2020, “Investing in your future”). BF-F was funded by Networking Biomedical Research Centre (CIBER). Publishing costs were provided by Networking Biomedical Research Centre (CIBER). These funding sources had no role in the design of this review, its execution, analyses, interpretation of the data, or decision to submit results.

Publisher Copyright:
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Keywords

adult intensive & critical care
epidemiology
infectious diseases

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/bmjopen-2019-035927

Cite this

Lopez-Alcalde, J., Antequera Martín, A., Stallings, E., Muriel, A., Fernández-Félix, B., Solà, I., Del Campo, R., Ponce-Alonso, M., Gordo, F., Fidalgo, P., Halperin, A. V., Álvarez-Díaz, N., Madrid-Pascual, O., Urrutia, G., & Zamora, J. (2020). Evaluation of the role of sex as a prognostic factor in critically ill adults with sepsis: Systematic review protocol. BMJ open, 10(5), Article e035927. https://doi.org/10.1136/bmjopen-2019-035927

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abstract = "Introduction Sepsis is a leading cause of mortality in critically ill patients. Recently, it has been recognised that sex may contribute to a differential risk for developing sepsis and it remains uncertain if the prognosis of sepsis varies between the sexes. The aim of this systematic review is to summarise the available evidence to assess the role of sex as a prognostic factor in patients with sepsis managed in the intensive care unit (ICU). Methods and analysis This is a systematic review protocol of prognostic studies of sex in patients with sepsis managed in the ICU. The primary outcomes include all-cause hospital mortality and all-cause hospital mortality during the first 28 days. The secondary outcomes include all-cause hospital mortality during the first 7 days and all-cause mortality at 1 year. We will conduct a search strategy based on the population (sepsis), the prognostic factor (sex), the outcome of interest (mortality) and prognostic study methods. We will search in the following databases up to December 2019: MEDLINE Ovid (from 1976), Embase Elsevier (from 1974), Web of Science and two trial registries. We will impose no language restrictions. Two authors will independently screen titles, abstracts and full-text articles for eligibility of studies, and subsequently extract data. Two authors will independently assess the risk of bias of each study using the Quality in Prognostic Studies (QUIPS) tool. If possible, we will carry out a meta-analysis to provide a pooled prognostic effect estimate for each outcome. We will use the Grading of Recommendations Assessment, Development and Evaluation system to assess the quality of evidence. Ethics and dissemination Ethical approval will not be required. Findings from this review will be reported in a peer-reviewed scientific journal. Additionally, the results will be disseminated at conferences and in the mass media. PROSPERO registration number CRD42019145054.",

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author = "Jesus Lopez-Alcalde and {Antequera Mart{\'i}n}, Alba and Elena Stallings and Alfonso Muriel and Borja Fern{\'a}ndez-F{\'e}lix and Ivan Sol{\`a} and {Del Campo}, Rosa and Manuel Ponce-Alonso and Federico Gordo and Pilar Fidalgo and Halperin, {Ana Ver{\'o}nica} and Noelia {\'A}lvarez-D{\'i}az and Olaya Madrid-Pascual and Gerard Urrutia and Javier Zamora",

note = "Funding Information: Funding The SEXCOMPLEX project was supported by Instituto de Salud Carlos III (Plan Estatal de I + D + i 2013–2016) and co-financed by the European Development Regional Fund 'A way to achieve Europe' (ERDF) grant number PIE16/00050. AAM was funded by the Instituto de Salud Carlos III through the “Acci{\'o}nEstrat{\'e}gica en Salud 2013–2016 / Contratos R{\'i}o Hortega call 2018/ CM18/00141” (Co-funded by European Social Fund 2014–2020, “Investing in your future”). BF-F was funded by Networking Biomedical Research Centre (CIBER). Publishing costs were provided by Networking Biomedical Research Centre (CIBER). These funding sources had no role in the design of this review, its execution, analyses, interpretation of the data, or decision to submit results. Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",

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Lopez-Alcalde, J, Antequera Martín, A, Stallings, E, Muriel, A, Fernández-Félix, B, Solà, I, Del Campo, R, Ponce-Alonso, M, Gordo, F, Fidalgo, P, Halperin, AV, Álvarez-Díaz, N, Madrid-Pascual, O, Urrutia, G & Zamora, J 2020, 'Evaluation of the role of sex as a prognostic factor in critically ill adults with sepsis: Systematic review protocol', BMJ open, vol. 10, no. 5, e035927. https://doi.org/10.1136/bmjopen-2019-035927

TY - JOUR

T1 - Evaluation of the role of sex as a prognostic factor in critically ill adults with sepsis

T2 - Systematic review protocol

AU - Lopez-Alcalde, Jesus

AU - Antequera Martín, Alba

AU - Stallings, Elena

AU - Muriel, Alfonso

AU - Fernández-Félix, Borja

AU - Solà, Ivan

AU - Del Campo, Rosa

AU - Ponce-Alonso, Manuel

AU - Gordo, Federico

AU - Fidalgo, Pilar

AU - Halperin, Ana Verónica

AU - Álvarez-Díaz, Noelia

AU - Madrid-Pascual, Olaya

AU - Urrutia, Gerard

AU - Zamora, Javier

N1 - Funding Information: Funding The SEXCOMPLEX project was supported by Instituto de Salud Carlos III (Plan Estatal de I + D + i 2013–2016) and co-financed by the European Development Regional Fund 'A way to achieve Europe' (ERDF) grant number PIE16/00050. AAM was funded by the Instituto de Salud Carlos III through the “AcciónEstratégica en Salud 2013–2016 / Contratos Río Hortega call 2018/ CM18/00141” (Co-funded by European Social Fund 2014–2020, “Investing in your future”). BF-F was funded by Networking Biomedical Research Centre (CIBER). Publishing costs were provided by Networking Biomedical Research Centre (CIBER). These funding sources had no role in the design of this review, its execution, analyses, interpretation of the data, or decision to submit results. Publisher Copyright: © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2020/5/6

Y1 - 2020/5/6

N2 - Introduction Sepsis is a leading cause of mortality in critically ill patients. Recently, it has been recognised that sex may contribute to a differential risk for developing sepsis and it remains uncertain if the prognosis of sepsis varies between the sexes. The aim of this systematic review is to summarise the available evidence to assess the role of sex as a prognostic factor in patients with sepsis managed in the intensive care unit (ICU). Methods and analysis This is a systematic review protocol of prognostic studies of sex in patients with sepsis managed in the ICU. The primary outcomes include all-cause hospital mortality and all-cause hospital mortality during the first 28 days. The secondary outcomes include all-cause hospital mortality during the first 7 days and all-cause mortality at 1 year. We will conduct a search strategy based on the population (sepsis), the prognostic factor (sex), the outcome of interest (mortality) and prognostic study methods. We will search in the following databases up to December 2019: MEDLINE Ovid (from 1976), Embase Elsevier (from 1974), Web of Science and two trial registries. We will impose no language restrictions. Two authors will independently screen titles, abstracts and full-text articles for eligibility of studies, and subsequently extract data. Two authors will independently assess the risk of bias of each study using the Quality in Prognostic Studies (QUIPS) tool. If possible, we will carry out a meta-analysis to provide a pooled prognostic effect estimate for each outcome. We will use the Grading of Recommendations Assessment, Development and Evaluation system to assess the quality of evidence. Ethics and dissemination Ethical approval will not be required. Findings from this review will be reported in a peer-reviewed scientific journal. Additionally, the results will be disseminated at conferences and in the mass media. PROSPERO registration number CRD42019145054.

AB - Introduction Sepsis is a leading cause of mortality in critically ill patients. Recently, it has been recognised that sex may contribute to a differential risk for developing sepsis and it remains uncertain if the prognosis of sepsis varies between the sexes. The aim of this systematic review is to summarise the available evidence to assess the role of sex as a prognostic factor in patients with sepsis managed in the intensive care unit (ICU). Methods and analysis This is a systematic review protocol of prognostic studies of sex in patients with sepsis managed in the ICU. The primary outcomes include all-cause hospital mortality and all-cause hospital mortality during the first 28 days. The secondary outcomes include all-cause hospital mortality during the first 7 days and all-cause mortality at 1 year. We will conduct a search strategy based on the population (sepsis), the prognostic factor (sex), the outcome of interest (mortality) and prognostic study methods. We will search in the following databases up to December 2019: MEDLINE Ovid (from 1976), Embase Elsevier (from 1974), Web of Science and two trial registries. We will impose no language restrictions. Two authors will independently screen titles, abstracts and full-text articles for eligibility of studies, and subsequently extract data. Two authors will independently assess the risk of bias of each study using the Quality in Prognostic Studies (QUIPS) tool. If possible, we will carry out a meta-analysis to provide a pooled prognostic effect estimate for each outcome. We will use the Grading of Recommendations Assessment, Development and Evaluation system to assess the quality of evidence. Ethics and dissemination Ethical approval will not be required. Findings from this review will be reported in a peer-reviewed scientific journal. Additionally, the results will be disseminated at conferences and in the mass media. PROSPERO registration number CRD42019145054.

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KW - epidemiology

KW - infectious diseases

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U2 - 10.1136/bmjopen-2019-035927

DO - 10.1136/bmjopen-2019-035927

M3 - Article

C2 - 32381536

AN - SCOPUS:85084397303

SN - 2044-6055

VL - 10

JO - BMJ open

JF - BMJ open

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ER -

Evaluation of the role of sex as a prognostic factor in critically ill adults with sepsis: Systematic review protocol

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Cite this