TY - JOUR
T1 - Ethnic/racial differences in circulating markers of angiogenesis and their association with cardiovascular risk factors and cardiovascular disease.
AU - Bennett, Philip
AU - Gill, Paramjit
AU - Silverman, Stanley
AU - Blann, Andrew
AU - Balakrishnan, B
AU - Lip, Gregory
PY - 2012/4/9
Y1 - 2012/4/9
N2 - OBJECTIVE: To determine (a) whether ethnic/racial differences exist in circulating markers of angiogenesis (Angiopoietin-1 (Ang-1), Angiopoietin-2 (Ang-2), soluble Tie-2 receptor (sTie-2) and Angiogenin) between South Asian (SA; from India, Pakistan and Bangladesh); Black African-Caribbean and White (W) ethnic groups, and (b) associations between these markers in stable cardiovascular disease (CVD) and its risk factors. PATIENTS AND METHODS: We recruited 243 subjects (82 SA, 84 Black and 77W) with symptomatic and clinically confirmed CVD (n=108), risk factor controls (with ≥1 cardiovascular risk factor, e.g. smoking, diabetes mellitus, dyslipidaemia, hypertension) and with ankle brachial pressure index >1) (n=64) and healthy controls free of CVD and risk factors (n=56). Angiogenic markers were measured by enzyme linked immunoassay. RESULTS: In healthy controls, angiogenin was higher in SA and Black subjects, compared to Whites (p
AB - OBJECTIVE: To determine (a) whether ethnic/racial differences exist in circulating markers of angiogenesis (Angiopoietin-1 (Ang-1), Angiopoietin-2 (Ang-2), soluble Tie-2 receptor (sTie-2) and Angiogenin) between South Asian (SA; from India, Pakistan and Bangladesh); Black African-Caribbean and White (W) ethnic groups, and (b) associations between these markers in stable cardiovascular disease (CVD) and its risk factors. PATIENTS AND METHODS: We recruited 243 subjects (82 SA, 84 Black and 77W) with symptomatic and clinically confirmed CVD (n=108), risk factor controls (with ≥1 cardiovascular risk factor, e.g. smoking, diabetes mellitus, dyslipidaemia, hypertension) and with ankle brachial pressure index >1) (n=64) and healthy controls free of CVD and risk factors (n=56). Angiogenic markers were measured by enzyme linked immunoassay. RESULTS: In healthy controls, angiogenin was higher in SA and Black subjects, compared to Whites (p
U2 - 10.1016/j.ijcard.2012.03.158
DO - 10.1016/j.ijcard.2012.03.158
M3 - Article
C2 - 22494858
VL - 167
SP - 1247
EP - 1250
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 4
ER -
