Epstein Barr virus entry; kissing and conjugation

Claire Shannon-Lowe, Martin Rowe

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Epstein Barr virus (EBV) is a highly prevalent human gamma 1 lymphocryptovirus which infects both B lymphocytes and epithelial cells. In the healthy host, infection of these different cell lineages broadly reflects the different phases of the virus lifecycle. Memory B cells are the reservoir for latent EBV, in which viral gene expression is highly restricted to maintain an asymptomatic lifelong infection. In contrast, epithelial cells may be a major site of the virus lytic cycle, where infectious virus is propagated and transmitted via saliva to uninfected hosts. To achieve this dual tropism, EBV has evolved a unique set of glycoproteins in addition to a highly conserved set, which interact with cell lineage-specific receptors and switch cellular tropism during infection.
Original languageEnglish
Pages (from-to)78-84
Number of pages7
JournalCurrent Opinion in Virology
Volume4C
DOIs
Publication statusPublished - 15 Feb 2014

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