Entry of hepatitis B and C viruses - recent progress and future impact

Thomas F Baumert; Luke Meredith; Yi Ni; Daniel J Felmlee; Jane A McKeating; Stephan Urban

doi:10.1016/j.coviro.2013.12.002

Entry of hepatitis B and C viruses - recent progress and future impact

Thomas F Baumert, Luke Meredith, Yi Ni, Daniel J Felmlee, Jane A McKeating, Stephan Urban

Immunology and Immunotherapy

Research output: Contribution to journal › Article

39 Citations (Scopus)

Abstract

Chronic hepatitis B and C virus infections are major causes of liver disease and hepatocellular carcinoma worldwide. Although both viruses infect hepatocytes, the molecular virology and cellular biology of their respective replication cycles differ. Viral entry is the first step of the life cycle and recent developments in functional genomic and proteomic methodologies have increased our understanding of the entry pathways for these two important human pathogens. In this review we provide a comparative analysis of the internalization routes for these viruses and highlight differences and how they impact the viral life cycle, immune responses and development of antivirals.

Original language	English
Pages (from-to)	58-65
Number of pages	8
Journal	Current Opinion in Virology
Volume	4
Early online date	14 Jan 2014
DOIs	https://doi.org/10.1016/j.coviro.2013.12.002
Publication status	Published - Feb 2014

Keywords

Hepacivirus
Hepatitis B virus
Humans
Virus Internalization

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.coviro.2013.12.002Licence: None: All rights reserved

https://doi.org/10.1016/j.coviro.2013.12.002Licence: None: All rights reserved

The Role of Hepatitis C Virus Glycoprotein-Receptor Polymorphism in Viral Pathogenesis
McKeating, J.
Medical Research Council
1/01/12 → 30/06/17
Project: Research Councils
Mechanisms of Hepatitis C Virus Induced Hepatocyte Injury
McKeating, J. & Balfe, P.
Medical Research Council
1/10/09 → 30/09/12
Project: Research Councils

Cite this

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title = "Entry of hepatitis B and C viruses - recent progress and future impact",

abstract = "Chronic hepatitis B and C virus infections are major causes of liver disease and hepatocellular carcinoma worldwide. Although both viruses infect hepatocytes, the molecular virology and cellular biology of their respective replication cycles differ. Viral entry is the first step of the life cycle and recent developments in functional genomic and proteomic methodologies have increased our understanding of the entry pathways for these two important human pathogens. In this review we provide a comparative analysis of the internalization routes for these viruses and highlight differences and how they impact the viral life cycle, immune responses and development of antivirals.",

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AU - Baumert, Thomas F

AU - Meredith, Luke

AU - Ni, Yi

AU - Felmlee, Daniel J

AU - McKeating, Jane A

AU - Urban, Stephan

PY - 2014/2

Y1 - 2014/2

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AB - Chronic hepatitis B and C virus infections are major causes of liver disease and hepatocellular carcinoma worldwide. Although both viruses infect hepatocytes, the molecular virology and cellular biology of their respective replication cycles differ. Viral entry is the first step of the life cycle and recent developments in functional genomic and proteomic methodologies have increased our understanding of the entry pathways for these two important human pathogens. In this review we provide a comparative analysis of the internalization routes for these viruses and highlight differences and how they impact the viral life cycle, immune responses and development of antivirals.

KW - Hepacivirus

KW - Hepatitis B virus

KW - Humans

KW - Virus Internalization

U2 - 10.1016/j.coviro.2013.12.002

DO - 10.1016/j.coviro.2013.12.002

M3 - Article

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SN - 1879-6257

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SP - 58

EP - 65

JO - Current Opinion in Virology

JF - Current Opinion in Virology

ER -

Entry of hepatitis B and C viruses - recent progress and future impact

Abstract

Keywords

UN SDGs

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Projects

The Role of Hepatitis C Virus Glycoprotein-Receptor Polymorphism in Viral Pathogenesis

Mechanisms of Hepatitis C Virus Induced Hepatocyte Injury

Cite this