Entry of hepatitis B and C viruses - recent progress and future impact

Thomas F Baumert, Luke Meredith, Yi Ni, Daniel J Felmlee, Jane A McKeating, Stephan Urban

Research output: Contribution to journalArticle

39 Citations (Scopus)


Chronic hepatitis B and C virus infections are major causes of liver disease and hepatocellular carcinoma worldwide. Although both viruses infect hepatocytes, the molecular virology and cellular biology of their respective replication cycles differ. Viral entry is the first step of the life cycle and recent developments in functional genomic and proteomic methodologies have increased our understanding of the entry pathways for these two important human pathogens. In this review we provide a comparative analysis of the internalization routes for these viruses and highlight differences and how they impact the viral life cycle, immune responses and development of antivirals.

Original languageEnglish
Pages (from-to)58-65
Number of pages8
JournalCurrent Opinion in Virology
Early online date14 Jan 2014
Publication statusPublished - Feb 2014


  • Hepacivirus
  • Hepatitis B virus
  • Humans
  • Virus Internalization


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