TY - JOUR
T1 - Enhancing 18F uptake in a single particle for positron emission particle tracking through modification of solid surface chemistry
AU - Fan, Xianfeng
AU - Parker, David
AU - Smith, Michael
PY - 2006/1/1
Y1 - 2006/1/1
N2 - The positron emission particle tracking (PEPT) technique has been widely used in science and engineering to obtain detailed information on particulate motion in granular materials and flow fields in multiphase systems. The technique involves tracking a single radioactively labelled particle by detecting the pairs of back-to-back 511 keV gamma-rays arising from annihilation of emitted positrons. It is thus crucially dependent on the availability of suitably labelled tracer particles. With the present equipment, the optimum activity for a PEPT tracer is between 300 and 1000 mu Ci. The positron emitting radionuclide most often used is F-18 in the form of fluoride ions. However, most materials have a very poor capacity to take up fluoride naturally. This paper presents a surface modification technique which was developed to improve the adsorption of tsF on solids and therefore extending the application of PEPT. For example. 200 mu m MCC particles are the subject of many PEPT studies, but these particles only adsorb a few mu Ci F-18 naturally, and cannot be used as tracers for PEPT. After surface modification, they take up about 700 mu Ci F-18, and can be tracked very well using PEPT. (c) 2006 Elsevier B.V. All rights reserved.
AB - The positron emission particle tracking (PEPT) technique has been widely used in science and engineering to obtain detailed information on particulate motion in granular materials and flow fields in multiphase systems. The technique involves tracking a single radioactively labelled particle by detecting the pairs of back-to-back 511 keV gamma-rays arising from annihilation of emitted positrons. It is thus crucially dependent on the availability of suitably labelled tracer particles. With the present equipment, the optimum activity for a PEPT tracer is between 300 and 1000 mu Ci. The positron emitting radionuclide most often used is F-18 in the form of fluoride ions. However, most materials have a very poor capacity to take up fluoride naturally. This paper presents a surface modification technique which was developed to improve the adsorption of tsF on solids and therefore extending the application of PEPT. For example. 200 mu m MCC particles are the subject of many PEPT studies, but these particles only adsorb a few mu Ci F-18 naturally, and cannot be used as tracers for PEPT. After surface modification, they take up about 700 mu Ci F-18, and can be tracked very well using PEPT. (c) 2006 Elsevier B.V. All rights reserved.
U2 - 10.1016/j.nima.2005.12.186
DO - 10.1016/j.nima.2005.12.186
M3 - Article
SN - 1872-9576
VL - 558
SP - 542
EP - 546
JO - Nuclear Instruments & Methods in Physics Research. Section A. Accelerators, Spectrometers, Detectors
JF - Nuclear Instruments & Methods in Physics Research. Section A. Accelerators, Spectrometers, Detectors
IS - 2-3
ER -