Effects of acute antipsychotic treatment on brain activation in first episode psychosis: An fMRI study

P. Fusar-Poli; M. R. Broome; P. Matthiasson; S. C.R. Williams; M. Brammer; P. K. McGuire

doi:10.1016/j.euroneuro.2007.01.003

Effects of acute antipsychotic treatment on brain activation in first episode psychosis: An fMRI study

P. Fusar-Poli^*, M. R. Broome, P. Matthiasson, S. C.R. Williams, M. Brammer, P. K. McGuire

^*Corresponding author for this work

Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

This study aimed to assess the neurophysiological effects of acute atypical antipsychotic treatment on cognitive functioning in subjects presenting with a first episode of psychosis. We used functional MRI to examine the modulatory effects of acute psychopharmacological intervention on brain activation during four different cognitive tasks: overt verbal fluency, random movement generation, n-back and a spatial object memory task. Treatment with atypical antipsychotics was associated with alterations in regional activation during each task and also when task demands were manipulated within paradigms. The initial treatment of psychosis with atypical antipsychotics thus appears to be associated with modifications of the neurofunctional correlates of executive and mnemonic functions. These effects need to be considered when interpreting group differences in activation between medicated patients and controls.

Original language	English
Pages (from-to)	492-500
Number of pages	9
Journal	European Neuropsychopharmacology
Volume	17
Issue number	6-7
DOIs	https://doi.org/10.1016/j.euroneuro.2007.01.003
Publication status	Published - May 2007

Bibliographical note

Funding Information:
The study was supported by grants from the Mental Health Foundation, Guy's and St Thomas' Charitable Foundation and GSK. These bodies were not involved in the design of the study, the collection and analysis of the data, or the interpretation of the results.

Keywords

Atypical antipsychotic
First episode psychosis
fMRI
Quetiapine
Risperidone

ASJC Scopus subject areas

Pharmacology
Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.euroneuro.2007.01.003

Cite this

@article{71eb3a68bd6c4575a1a71d7b1e115361,

title = "Effects of acute antipsychotic treatment on brain activation in first episode psychosis: An fMRI study",

abstract = "This study aimed to assess the neurophysiological effects of acute atypical antipsychotic treatment on cognitive functioning in subjects presenting with a first episode of psychosis. We used functional MRI to examine the modulatory effects of acute psychopharmacological intervention on brain activation during four different cognitive tasks: overt verbal fluency, random movement generation, n-back and a spatial object memory task. Treatment with atypical antipsychotics was associated with alterations in regional activation during each task and also when task demands were manipulated within paradigms. The initial treatment of psychosis with atypical antipsychotics thus appears to be associated with modifications of the neurofunctional correlates of executive and mnemonic functions. These effects need to be considered when interpreting group differences in activation between medicated patients and controls.",

keywords = "Atypical antipsychotic, First episode psychosis, fMRI, Quetiapine, Risperidone",

author = "P. Fusar-Poli and Broome, {M. R.} and P. Matthiasson and Williams, {S. C.R.} and M. Brammer and McGuire, {P. K.}",

note = "Funding Information: The study was supported by grants from the Mental Health Foundation, Guy's and St Thomas' Charitable Foundation and GSK. These bodies were not involved in the design of the study, the collection and analysis of the data, or the interpretation of the results. ",

year = "2007",

month = may,

doi = "10.1016/j.euroneuro.2007.01.003",

language = "English",

volume = "17",

pages = "492--500",

journal = "European Neuropsychopharmacology",

issn = "0924-977X",

publisher = "Elsevier",

number = "6-7",

}

TY - JOUR

T1 - Effects of acute antipsychotic treatment on brain activation in first episode psychosis

T2 - An fMRI study

AU - Fusar-Poli, P.

AU - Broome, M. R.

AU - Matthiasson, P.

AU - Williams, S. C.R.

AU - Brammer, M.

AU - McGuire, P. K.

N1 - Funding Information: The study was supported by grants from the Mental Health Foundation, Guy's and St Thomas' Charitable Foundation and GSK. These bodies were not involved in the design of the study, the collection and analysis of the data, or the interpretation of the results.

PY - 2007/5

Y1 - 2007/5

N2 - This study aimed to assess the neurophysiological effects of acute atypical antipsychotic treatment on cognitive functioning in subjects presenting with a first episode of psychosis. We used functional MRI to examine the modulatory effects of acute psychopharmacological intervention on brain activation during four different cognitive tasks: overt verbal fluency, random movement generation, n-back and a spatial object memory task. Treatment with atypical antipsychotics was associated with alterations in regional activation during each task and also when task demands were manipulated within paradigms. The initial treatment of psychosis with atypical antipsychotics thus appears to be associated with modifications of the neurofunctional correlates of executive and mnemonic functions. These effects need to be considered when interpreting group differences in activation between medicated patients and controls.

AB - This study aimed to assess the neurophysiological effects of acute atypical antipsychotic treatment on cognitive functioning in subjects presenting with a first episode of psychosis. We used functional MRI to examine the modulatory effects of acute psychopharmacological intervention on brain activation during four different cognitive tasks: overt verbal fluency, random movement generation, n-back and a spatial object memory task. Treatment with atypical antipsychotics was associated with alterations in regional activation during each task and also when task demands were manipulated within paradigms. The initial treatment of psychosis with atypical antipsychotics thus appears to be associated with modifications of the neurofunctional correlates of executive and mnemonic functions. These effects need to be considered when interpreting group differences in activation between medicated patients and controls.

KW - Atypical antipsychotic

KW - First episode psychosis

KW - fMRI

KW - Quetiapine

KW - Risperidone

UR - http://www.scopus.com/inward/record.url?scp=34047175288&partnerID=8YFLogxK

U2 - 10.1016/j.euroneuro.2007.01.003

DO - 10.1016/j.euroneuro.2007.01.003

M3 - Article

C2 - 17337340

AN - SCOPUS:34047175288

SN - 0924-977X

VL - 17

SP - 492

EP - 500

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

IS - 6-7

ER -

Effects of acute antipsychotic treatment on brain activation in first episode psychosis: An fMRI study

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Fingerprint

Cite this