Abstract
This study aimed to assess the neurophysiological effects of acute atypical antipsychotic treatment on cognitive functioning in subjects presenting with a first episode of psychosis. We used functional MRI to examine the modulatory effects of acute psychopharmacological intervention on brain activation during four different cognitive tasks: overt verbal fluency, random movement generation, n-back and a spatial object memory task. Treatment with atypical antipsychotics was associated with alterations in regional activation during each task and also when task demands were manipulated within paradigms. The initial treatment of psychosis with atypical antipsychotics thus appears to be associated with modifications of the neurofunctional correlates of executive and mnemonic functions. These effects need to be considered when interpreting group differences in activation between medicated patients and controls.
Original language | English |
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Pages (from-to) | 492-500 |
Number of pages | 9 |
Journal | European Neuropsychopharmacology |
Volume | 17 |
Issue number | 6-7 |
DOIs | |
Publication status | Published - May 2007 |
Bibliographical note
Funding Information:The study was supported by grants from the Mental Health Foundation, Guy's and St Thomas' Charitable Foundation and GSK. These bodies were not involved in the design of the study, the collection and analysis of the data, or the interpretation of the results.
Keywords
- Atypical antipsychotic
- First episode psychosis
- fMRI
- Quetiapine
- Risperidone
ASJC Scopus subject areas
- Pharmacology
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry
- Pharmacology (medical)