TY - JOUR
T1 - Effect of aortic valve replacement on plasma soluble P-selectin, von Willebrand factor, and fibrinogen
AU - Goldsmith, Ira
AU - Blann, Andrew
AU - Patel, RL
AU - Lip, Gregory
PY - 2001/1/1
Y1 - 2001/1/1
N2 - We measured indexes of platelet activation (soluble P-selectin), endothelial dysfunction (von Willebrand factor), and fibrinogen in 54 patients who underwent aortic valve replacement (AVR): after mechanical AVR implantation, there was a significant increase in plasma levels of soluble P-selectin and von Willebrand factor levels 3 months after surgery, with no change in mean plasma fibrinogen levels. No significant changes in measured indexes were noted in patients undergoing biologic AVR, suggesting that mechanical AVR results in abnormal endothelial damage and/or dysfunction and platelet activation, which is not apparent among patients undergoing this procedure.
AB - We measured indexes of platelet activation (soluble P-selectin), endothelial dysfunction (von Willebrand factor), and fibrinogen in 54 patients who underwent aortic valve replacement (AVR): after mechanical AVR implantation, there was a significant increase in plasma levels of soluble P-selectin and von Willebrand factor levels 3 months after surgery, with no change in mean plasma fibrinogen levels. No significant changes in measured indexes were noted in patients undergoing biologic AVR, suggesting that mechanical AVR results in abnormal endothelial damage and/or dysfunction and platelet activation, which is not apparent among patients undergoing this procedure.
UR - http://www.scopus.com/inward/record.url?scp=0035191753&partnerID=8YFLogxK
U2 - 10.1016/S0002-9149(00)01283-2
DO - 10.1016/S0002-9149(00)01283-2
M3 - Article
C2 - 11137845
SN - 1879-1913
VL - 87
SP - 107
EP - 110
JO - The American Journal of Cardiology
JF - The American Journal of Cardiology
IS - 1
ER -