Effect of administration of oral contraceptives on the synthesis and breakdown of myofibrillar proteins in young women

M Hansen; Henning Langberg; Lars Holm; B F Miller; S.G. Petersen; Simon Doessing; D Skovgaard; T. Trappe; Michael Kjær

doi:10.1111/j.1600-0838.2009.01002.x

Effect of administration of oral contraceptives on the synthesis and breakdown of myofibrillar proteins in young women

M Hansen, Henning Langberg, Lars Holm, B F Miller, S.G. Petersen, Simon Doessing, D Skovgaard, T. Trappe, Michael Kjær

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Oral contraceptive (OC) treatment has an inhibiting effect on protein synthesis in tendon and muscle connective tissue. We aimed to investigate whether OC influence myofibrillar protein turnover in young women. OC-users (24±2 years; Lindynette® n=7, Cilest® n=4) and non-OC-users (controls, 24±4 years n=12) performed one-legged kicking exercise. The next day, the myofibrillar protein fractional synthesis rate (FSR) was measured using stable isotopic tracers ((13)C-proline) while the subjects were fed standardized nutrient drinks. Simultaneously, a marker for myofibrillar protein breakdown, 3-methyl-histidine (3-MH), was measured in the interstitial fluid of the vastus lateralis. Measurements were performed in both legs. In general, myofibrillar protein FSR was lower in OC-users (two-way analysis of variance, P

Original language	English
Pages (from-to)	62-72
Number of pages	11
Journal	Scandinavian Journal of Medicine and Science in Sports
Volume	21
Issue number	1
DOIs	https://doi.org/10.1111/j.1600-0838.2009.01002.x
Publication status	Published - 11 Feb 2011

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title = "Effect of administration of oral contraceptives on the synthesis and breakdown of myofibrillar proteins in young women",

abstract = "Oral contraceptive (OC) treatment has an inhibiting effect on protein synthesis in tendon and muscle connective tissue. We aimed to investigate whether OC influence myofibrillar protein turnover in young women. OC-users (24±2 years; Lindynette{\textregistered} n=7, Cilest{\textregistered} n=4) and non-OC-users (controls, 24±4 years n=12) performed one-legged kicking exercise. The next day, the myofibrillar protein fractional synthesis rate (FSR) was measured using stable isotopic tracers ((13)C-proline) while the subjects were fed standardized nutrient drinks. Simultaneously, a marker for myofibrillar protein breakdown, 3-methyl-histidine (3-MH), was measured in the interstitial fluid of the vastus lateralis. Measurements were performed in both legs. In general, myofibrillar protein FSR was lower in OC-users (two-way analysis of variance, P",

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AU - Hansen, M

AU - Langberg, Henning

AU - Holm, Lars

AU - Miller, B F

AU - Petersen, S.G.

AU - Doessing, Simon

AU - Skovgaard, D

AU - Trappe, T.

AU - Kjær, Michael

PY - 2011/2/11

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AB - Oral contraceptive (OC) treatment has an inhibiting effect on protein synthesis in tendon and muscle connective tissue. We aimed to investigate whether OC influence myofibrillar protein turnover in young women. OC-users (24±2 years; Lindynette® n=7, Cilest® n=4) and non-OC-users (controls, 24±4 years n=12) performed one-legged kicking exercise. The next day, the myofibrillar protein fractional synthesis rate (FSR) was measured using stable isotopic tracers ((13)C-proline) while the subjects were fed standardized nutrient drinks. Simultaneously, a marker for myofibrillar protein breakdown, 3-methyl-histidine (3-MH), was measured in the interstitial fluid of the vastus lateralis. Measurements were performed in both legs. In general, myofibrillar protein FSR was lower in OC-users (two-way analysis of variance, P

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DO - 10.1111/j.1600-0838.2009.01002.x

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JO - Scandinavian Journal of Medicine and Science in Sports

JF - Scandinavian Journal of Medicine and Science in Sports

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Effect of administration of oral contraceptives on the synthesis and breakdown of myofibrillar proteins in young women

Abstract

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