Economic evaluation of typhoid: a review of typhoid cost-effectiveness studies

Samuel Frempong, Andrew Sutton, Clare Davenport, Pelham Barton

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Introduction: To evaluate the potential economic value and likely impact of a hypothetical rapid test in its early stages of development requires the use of models. The model structure and the type of model (dynamic/static) to employ are key considerations. The aim of the review was to explore the literature on typhoid economic evaluations, and to explore the types of models that have been previously adopted in this setting for test-treat evaluations and to capture data on model inputs that may be useful for a de novo model. Areas Covered: A systematic review was conducted to identify economic evaluations focused on typhoid in established literature databases. Eight studies were identified and included for narrative synthesis. The review has revealed that there have been relatively few economic evaluations that have focussed on typhoid fever, all of which have focused on the impact of interventions at the population level (vaccination) but not the individual level (test-treat strategies). Expert commentary: Under certain circumstances, either a static model or a transmission dynamic model may be appropriate in the evaluation of an intervention for typhoid fever. Typhoid test-treat modelling represents a grey area where further work is needed.
Original languageEnglish
JournalExpert Review of Pharmacoeconomics & Outcomes Research
Early online date30 Jul 2018
Publication statusE-pub ahead of print - 30 Jul 2018


  • cost-benefit analysis
  • cost-utility analysis
  • cost-effectiveness analysis
  • economic evaluation
  • enteric fever
  • review
  • typhoid fever


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