Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort

Charlotte Jackson; Jo Southern; Ajit Lalvani; Francis Drobniewski; Christopher J Griffiths; Marc Lipman; Graham H Bothamley; Jonathan Deeks; Ambreen Imran; Onn Min Kon; Sithembinkosi Mpofu; Vladyslav Nikolayevskyy; Melanie Rees-Roberts; Alice Sitch; Saranya Sridhar; Chuen-Yan Tsou; Hilary Whitworth; Ibrahim Abubakar

doi:10.1136/thoraxjnl-2017-211124

Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort

Charlotte Jackson, Jo Southern, Ajit Lalvani, Francis Drobniewski, Christopher J Griffiths, Marc Lipman, Graham H Bothamley, Jonathan Deeks, Ambreen Imran, Onn Min Kon, Sithembinkosi Mpofu, Vladyslav Nikolayevskyy, Melanie Rees-Roberts, Alice Sitch, Saranya Sridhar, Chuen-Yan Tsou, Hilary Whitworth, Ibrahim Abubakar

Applied Health Research

Research output: Contribution to journal › Letter › peer-review

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Abstract

We conducted a cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI, defined as a positive result for either of the two interferon gamma release assays). Binomial regression with a log link was used to estimate crude and adjusted prevalence ratios (PRs) and 95% CIs for the relationship between diabetes mellitus (DM) and LTBI. Adjusted for age, sex, ethnicity, body mass index and the presence of other immunocompromising conditions, DM was associated with a 15% higher prevalence of LTBI (adjusted PR=1.15, 95% CI 1.02 to 1.30, p=0.025).

Original language	English
Journal	Thorax
Early online date	15 May 2018
DOIs	https://doi.org/10.1136/thoraxjnl-2017-211124
Publication status	E-pub ahead of print - 15 May 2018

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Jackson_et_al_Diabetes_mellitus_and_latent_tuberculosis_Thorax_2018
Checked for eligibility: 10/04/2018 Final version of record available at: http://dx.doi.org/10.1136/thoraxjnl-2017-211124
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Jackson, C., Southern, J., Lalvani, A., Drobniewski, F., Griffiths, C. J., Lipman, M., Bothamley, G. H., Deeks, J., Imran, A., Kon, O. M., Mpofu, S., Nikolayevskyy, V., Rees-Roberts, M., Sitch, A., Sridhar, S., Tsou, C.-Y., Whitworth, H., & Abubakar, I. (2018). Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort. Thorax. Advance online publication. https://doi.org/10.1136/thoraxjnl-2017-211124

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title = "Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort",

abstract = "We conducted a cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI, defined as a positive result for either of the two interferon gamma release assays). Binomial regression with a log link was used to estimate crude and adjusted prevalence ratios (PRs) and 95% CIs for the relationship between diabetes mellitus (DM) and LTBI. Adjusted for age, sex, ethnicity, body mass index and the presence of other immunocompromising conditions, DM was associated with a 15% higher prevalence of LTBI (adjusted PR=1.15, 95% CI 1.02 to 1.30, p=0.025).",

author = "Charlotte Jackson and Jo Southern and Ajit Lalvani and Francis Drobniewski and Griffiths, {Christopher J} and Marc Lipman and Bothamley, {Graham H} and Jonathan Deeks and Ambreen Imran and Kon, {Onn Min} and Sithembinkosi Mpofu and Vladyslav Nikolayevskyy and Melanie Rees-Roberts and Alice Sitch and Saranya Sridhar and Chuen-Yan Tsou and Hilary Whitworth and Ibrahim Abubakar",

year = "2018",

month = may,

day = "15",

doi = "10.1136/thoraxjnl-2017-211124",

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journal = "Thorax",

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Jackson, C, Southern, J, Lalvani, A, Drobniewski, F, Griffiths, CJ, Lipman, M, Bothamley, GH, Deeks, J, Imran, A, Kon, OM, Mpofu, S, Nikolayevskyy, V, Rees-Roberts, M, Sitch, A, Sridhar, S, Tsou, C-Y, Whitworth, H & Abubakar, I 2018, 'Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort', Thorax. https://doi.org/10.1136/thoraxjnl-2017-211124

TY - JOUR

T1 - Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort

AU - Jackson, Charlotte

AU - Southern, Jo

AU - Lalvani, Ajit

AU - Drobniewski, Francis

AU - Griffiths, Christopher J

AU - Lipman, Marc

AU - Bothamley, Graham H

AU - Deeks, Jonathan

AU - Imran, Ambreen

AU - Kon, Onn Min

AU - Mpofu, Sithembinkosi

AU - Nikolayevskyy, Vladyslav

AU - Rees-Roberts, Melanie

AU - Sitch, Alice

AU - Sridhar, Saranya

AU - Tsou, Chuen-Yan

AU - Whitworth, Hilary

AU - Abubakar, Ibrahim

PY - 2018/5/15

Y1 - 2018/5/15

N2 - We conducted a cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI, defined as a positive result for either of the two interferon gamma release assays). Binomial regression with a log link was used to estimate crude and adjusted prevalence ratios (PRs) and 95% CIs for the relationship between diabetes mellitus (DM) and LTBI. Adjusted for age, sex, ethnicity, body mass index and the presence of other immunocompromising conditions, DM was associated with a 15% higher prevalence of LTBI (adjusted PR=1.15, 95% CI 1.02 to 1.30, p=0.025).

AB - We conducted a cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI, defined as a positive result for either of the two interferon gamma release assays). Binomial regression with a log link was used to estimate crude and adjusted prevalence ratios (PRs) and 95% CIs for the relationship between diabetes mellitus (DM) and LTBI. Adjusted for age, sex, ethnicity, body mass index and the presence of other immunocompromising conditions, DM was associated with a 15% higher prevalence of LTBI (adjusted PR=1.15, 95% CI 1.02 to 1.30, p=0.025).

U2 - 10.1136/thoraxjnl-2017-211124

DO - 10.1136/thoraxjnl-2017-211124

M3 - Letter

SN - 0040-6376

JO - Thorax

JF - Thorax

ER -

Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort

Abstract

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