Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort

Charlotte Jackson, Jo Southern, Ajit Lalvani, Francis Drobniewski, Christopher J Griffiths, Marc Lipman, Graham H Bothamley, Jonathan Deeks, Ambreen Imran, Onn Min Kon, Sithembinkosi Mpofu, Vladyslav Nikolayevskyy, Melanie Rees-Roberts, Alice Sitch, Saranya Sridhar, Chuen-Yan Tsou, Hilary Whitworth, Ibrahim Abubakar

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Abstract

We conducted a cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI, defined as a positive result for either of the two interferon gamma release assays). Binomial regression with a log link was used to estimate crude and adjusted prevalence ratios (PRs) and 95% CIs for the relationship between diabetes mellitus (DM) and LTBI. Adjusted for age, sex, ethnicity, body mass index and the presence of other immunocompromising conditions, DM was associated with a 15% higher prevalence of LTBI (adjusted PR=1.15, 95% CI 1.02 to 1.30, p=0.025).
Original languageEnglish
JournalThorax
Early online date15 May 2018
DOIs
Publication statusE-pub ahead of print - 15 May 2018

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