TY - JOUR
T1 - Determinants of Rad21 localization at the centrosome in human cells.
AU - Tsai, Hung-Ji
PY - 2010/5/15
Y1 - 2010/5/15
N2 - Cohesin proteins help maintain the physical associations between sister chromatids that arise in S-phase and are removed in anaphase. Recent studies found that cohesins also localize to the centrosomes, the organelles that organize the mitotic bipolar spindle. We find that the cohesin protein Rad21 localizes to centrosomes in a manner that is dependent upon known regulators of sister chromatid cohesion as well as regulators of centrosome function. These data suggest that Rad21 functions at the centrosome and that the regulators of Rad21 coordinate the centrosome and chromosomal functions of cohesin.
AB - Cohesin proteins help maintain the physical associations between sister chromatids that arise in S-phase and are removed in anaphase. Recent studies found that cohesins also localize to the centrosomes, the organelles that organize the mitotic bipolar spindle. We find that the cohesin protein Rad21 localizes to centrosomes in a manner that is dependent upon known regulators of sister chromatid cohesion as well as regulators of centrosome function. These data suggest that Rad21 functions at the centrosome and that the regulators of Rad21 coordinate the centrosome and chromosomal functions of cohesin.
UR - https://doi.org/10.4161/cc.9.9.11523
U2 - 10.4161/cc.9.9.11523
DO - 10.4161/cc.9.9.11523
M3 - Article
C2 - 20404544
VL - 9
JO - Cell cycle (Georgetown, Tex.)
JF - Cell cycle (Georgetown, Tex.)
IS - 9
ER -