TY - UNPB
T1 - Detection of the 40-Hz auditory steady-state response with optically pumped magnetometers
AU - An, Kyung-min
AU - Shim, Jung Hyun
AU - Kwon, Hyukchan
AU - Lee, Yong-Ho
AU - Yu, Kwon-Kyu
AU - Kwon, Moonyoung
AU - Chun, Woo Young
AU - Hirosawa, Tetsu
AU - Hasegawa, Chiaki
AU - Iwasaki, Sumie
AU - Kikuchi, Mitsuru
AU - Kim, Kiwoong
PY - 2021/10/3
Y1 - 2021/10/3
N2 - Magnetoencephalography (MEG) is a functional neuroimaging technique that noninvasively detects the brain magnetic field from neuronal activations. Conventional MEG measures brain signals using superconducting quantum interference devices (SQUIDs). SQUID-MEG requires a cryogenic environment involving a bulky non-magnetic dewar and the consumption of liquid helium, which restricts the variability of the sensor array and the gap between the cortical sources and sensors. Recently, miniature optically pumped magnetometers (OPMs) have been developed and commercialized. OPMs do not require cryogenic cooling and can be placed within millimeters from the scalp. In the present study, we arranged six OPM sensors on the temporal area to detect auditory-related brain responses in a two-layer magnetically shielded room. We presented the auditory stimuli of 1-kHz pure-tone bursts with 200-ms duration and obtained the M50 and M100 components of auditory evoked fields. We delivered the periodic stimuli with a 40-Hz repetition rate and observed the gamma-band power changes and inter-trial phase coherence of auditory steady-state responses at 40 Hz. We found that the OPM sensors have a performance comparable to that of conventional SQUID-MEG sensors, and our results suggest the feasibility of using OPM sensors for functional neuroimaging and brain–computer interface applications.
AB - Magnetoencephalography (MEG) is a functional neuroimaging technique that noninvasively detects the brain magnetic field from neuronal activations. Conventional MEG measures brain signals using superconducting quantum interference devices (SQUIDs). SQUID-MEG requires a cryogenic environment involving a bulky non-magnetic dewar and the consumption of liquid helium, which restricts the variability of the sensor array and the gap between the cortical sources and sensors. Recently, miniature optically pumped magnetometers (OPMs) have been developed and commercialized. OPMs do not require cryogenic cooling and can be placed within millimeters from the scalp. In the present study, we arranged six OPM sensors on the temporal area to detect auditory-related brain responses in a two-layer magnetically shielded room. We presented the auditory stimuli of 1-kHz pure-tone bursts with 200-ms duration and obtained the M50 and M100 components of auditory evoked fields. We delivered the periodic stimuli with a 40-Hz repetition rate and observed the gamma-band power changes and inter-trial phase coherence of auditory steady-state responses at 40 Hz. We found that the OPM sensors have a performance comparable to that of conventional SQUID-MEG sensors, and our results suggest the feasibility of using OPM sensors for functional neuroimaging and brain–computer interface applications.
KW - optically pumped magnetometer
KW - magnetoencephalography
KW - auditory evoked fields
KW - auditory steady-state response
KW - gamma
U2 - 10.1101/2021.10.01.462598
DO - 10.1101/2021.10.01.462598
M3 - Preprint
BT - Detection of the 40-Hz auditory steady-state response with optically pumped magnetometers
PB - bioRxiv
ER -