Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis

Emmet E McGrath; Allan Lawrie; Helen M Marriott; Paul Mercer; Simon S Cross; Nadine Arnold; Vanessa Singleton; Alfred A R Thompson; Sarah R Walmsley; Stephen A Renshaw; Ian Sabroe; Rachel C Chambers; David H Dockrell; Moira K B Whyte

doi:10.1136/thoraxjnl-2011-200863

Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis

Emmet E McGrath, Allan Lawrie, Helen M Marriott, Paul Mercer, Simon S Cross, Nadine Arnold, Vanessa Singleton, Alfred A R Thompson, Sarah R Walmsley, Stephen A Renshaw, Ian Sabroe, Rachel C Chambers, David H Dockrell, Moira K B Whyte

Cardiovascular Sciences

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

The death receptor ligand tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) shows considerable clinical promise as a therapeutic agent. TRAIL induces leukocyte apoptosis, reducing acute inflammatory responses in the lung. It is not known whether TRAIL modifies chronic lung injury or whether TRAIL has a role in human idiopathic pulmonary fibrosis (IPF). We therefore explored the capacity of TRAIL to modify chronic inflammatory lung injury and studied TRAIL expression in patients with IPF.

Original language	English
Pages (from-to)	796-803
Number of pages	8
Journal	Thorax
Volume	67
Issue number	9
DOIs	https://doi.org/10.1136/thoraxjnl-2011-200863
Publication status	Published - 2012

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McGrath, E. E., Lawrie, A., Marriott, H. M., Mercer, P., Cross, S. S., Arnold, N., Singleton, V., Thompson, A. A. R., Walmsley, S. R., Renshaw, S. A., Sabroe, I., Chambers, R. C., Dockrell, D. H., & Whyte, M. K. B. (2012). Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis. Thorax, 67(9), 796-803. https://doi.org/10.1136/thoraxjnl-2011-200863

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abstract = "The death receptor ligand tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) shows considerable clinical promise as a therapeutic agent. TRAIL induces leukocyte apoptosis, reducing acute inflammatory responses in the lung. It is not known whether TRAIL modifies chronic lung injury or whether TRAIL has a role in human idiopathic pulmonary fibrosis (IPF). We therefore explored the capacity of TRAIL to modify chronic inflammatory lung injury and studied TRAIL expression in patients with IPF.",

author = "McGrath, {Emmet E} and Allan Lawrie and Marriott, {Helen M} and Paul Mercer and Cross, {Simon S} and Nadine Arnold and Vanessa Singleton and Thompson, {Alfred A R} and Walmsley, {Sarah R} and Renshaw, {Stephen A} and Ian Sabroe and Chambers, {Rachel C} and Dockrell, {David H} and Whyte, {Moira K B}",

year = "2012",

doi = "10.1136/thoraxjnl-2011-200863",

language = "English",

volume = "67",

pages = "796--803",

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McGrath, EE, Lawrie, A, Marriott, HM, Mercer, P, Cross, SS, Arnold, N, Singleton, V, Thompson, AAR, Walmsley, SR, Renshaw, SA, Sabroe, I, Chambers, RC, Dockrell, DH & Whyte, MKB 2012, 'Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis', Thorax, vol. 67, no. 9, pp. 796-803. https://doi.org/10.1136/thoraxjnl-2011-200863

TY - JOUR

T1 - Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis

AU - McGrath, Emmet E

AU - Lawrie, Allan

AU - Marriott, Helen M

AU - Mercer, Paul

AU - Cross, Simon S

AU - Arnold, Nadine

AU - Singleton, Vanessa

AU - Thompson, Alfred A R

AU - Walmsley, Sarah R

AU - Renshaw, Stephen A

AU - Sabroe, Ian

AU - Chambers, Rachel C

AU - Dockrell, David H

AU - Whyte, Moira K B

PY - 2012

Y1 - 2012

N2 - The death receptor ligand tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) shows considerable clinical promise as a therapeutic agent. TRAIL induces leukocyte apoptosis, reducing acute inflammatory responses in the lung. It is not known whether TRAIL modifies chronic lung injury or whether TRAIL has a role in human idiopathic pulmonary fibrosis (IPF). We therefore explored the capacity of TRAIL to modify chronic inflammatory lung injury and studied TRAIL expression in patients with IPF.

AB - The death receptor ligand tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) shows considerable clinical promise as a therapeutic agent. TRAIL induces leukocyte apoptosis, reducing acute inflammatory responses in the lung. It is not known whether TRAIL modifies chronic lung injury or whether TRAIL has a role in human idiopathic pulmonary fibrosis (IPF). We therefore explored the capacity of TRAIL to modify chronic inflammatory lung injury and studied TRAIL expression in patients with IPF.

U2 - 10.1136/thoraxjnl-2011-200863

DO - 10.1136/thoraxjnl-2011-200863

M3 - Article

C2 - 22496351

SN - 1468-3296

VL - 67

SP - 796

EP - 803

JO - Thorax

JF - Thorax

IS - 9

ER -

Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis

Abstract

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