TY - JOUR
T1 - Deconstructing the integrated oscillator model for pancreatic β -cells
AU - Bertram, Richard
AU - Marinelli, Isabella
AU - Fletcher, Patrick A.
AU - Satin, Leslie S.
AU - Sherman, Arthur S.
PY - 2023/11
Y1 - 2023/11
N2 - Electrical bursting oscillations in the
β
-cells of pancreatic islets have been a focus of investigation for more than fifty years. This has been aided by mathematical models, which are descendants of the pioneering Chay–Keizer model. This article describes the key biophysical and mathematical elements of this model, and then describes the path forward from there to the Integrated Oscillator Model (IOM). It is both a history and a deconstruction of the IOM that describes the various elements that have been added to the model over time, and the motivation for adding them. Finally, the article is a celebration of the 40th anniversary of the publication of the Chay–Keizer model.
AB - Electrical bursting oscillations in the
β
-cells of pancreatic islets have been a focus of investigation for more than fifty years. This has been aided by mathematical models, which are descendants of the pioneering Chay–Keizer model. This article describes the key biophysical and mathematical elements of this model, and then describes the path forward from there to the Integrated Oscillator Model (IOM). It is both a history and a deconstruction of the IOM that describes the various elements that have been added to the model over time, and the motivation for adding them. Finally, the article is a celebration of the 40th anniversary of the publication of the Chay–Keizer model.
U2 - 10.1016/j.mbs.2023.109085
DO - 10.1016/j.mbs.2023.109085
M3 - Article
SN - 0025-5564
VL - 365
JO - Mathematical biosciences
JF - Mathematical biosciences
M1 - 109085
ER -