Crystallization of amorphous lactose at high humidity studied by terahertz time domain spectroscopy

Alexander I. McIntosh; Bin Yang; Stephen M. Goldup; Michael Watkinson; Robert S. Donnan

doi:10.1016/j.cplett.2012.12.044

Crystallization of amorphous lactose at high humidity studied by terahertz time domain spectroscopy

Alexander I. McIntosh, Bin Yang, Stephen M. Goldup, Michael Watkinson, Robert S. Donnan^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

We report the first use of terahertz time-domain spectroscopy (THz-TDS) to study the hydration and crystallization of an amorphous molecular solid at high humidity. Lactose in its amorphous and monohydrate forms exhibits different terahertz spectra due to the lack of long range order in the amorphous material. This difference allowed the transformation of amorphous lactose to its monohydrate form at high humidity to be studied in real time. Spectral fitting of frequency-domain data allowed kinetic data to be obtained and the crystallization was found to obey Avrami kinetics. Bulk changes during the crystallization could also be observed in the time-domain.

Original language	English
Pages (from-to)	104-108
Number of pages	5
Journal	Chemical Physics Letters
Volume	558
DOIs	https://doi.org/10.1016/j.cplett.2012.12.044
Publication status	Published - 12 Feb 2013

Bibliographical note

Funding Information:
The authors thank the Engineering and Physical Sciences Research Council (EPSRC) of UK for financial support under Grant EP/1014845/1 .

ASJC Scopus subject areas

General Physics and Astronomy
Physical and Theoretical Chemistry

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title = "Crystallization of amorphous lactose at high humidity studied by terahertz time domain spectroscopy",

abstract = "We report the first use of terahertz time-domain spectroscopy (THz-TDS) to study the hydration and crystallization of an amorphous molecular solid at high humidity. Lactose in its amorphous and monohydrate forms exhibits different terahertz spectra due to the lack of long range order in the amorphous material. This difference allowed the transformation of amorphous lactose to its monohydrate form at high humidity to be studied in real time. Spectral fitting of frequency-domain data allowed kinetic data to be obtained and the crystallization was found to obey Avrami kinetics. Bulk changes during the crystallization could also be observed in the time-domain.",

author = "McIntosh, {Alexander I.} and Bin Yang and Goldup, {Stephen M.} and Michael Watkinson and Donnan, {Robert S.}",

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AU - McIntosh, Alexander I.

AU - Yang, Bin

AU - Goldup, Stephen M.

AU - Watkinson, Michael

AU - Donnan, Robert S.

N1 - Funding Information: The authors thank the Engineering and Physical Sciences Research Council (EPSRC) of UK for financial support under Grant EP/1014845/1 .

PY - 2013/2/12

Y1 - 2013/2/12

N2 - We report the first use of terahertz time-domain spectroscopy (THz-TDS) to study the hydration and crystallization of an amorphous molecular solid at high humidity. Lactose in its amorphous and monohydrate forms exhibits different terahertz spectra due to the lack of long range order in the amorphous material. This difference allowed the transformation of amorphous lactose to its monohydrate form at high humidity to be studied in real time. Spectral fitting of frequency-domain data allowed kinetic data to be obtained and the crystallization was found to obey Avrami kinetics. Bulk changes during the crystallization could also be observed in the time-domain.

AB - We report the first use of terahertz time-domain spectroscopy (THz-TDS) to study the hydration and crystallization of an amorphous molecular solid at high humidity. Lactose in its amorphous and monohydrate forms exhibits different terahertz spectra due to the lack of long range order in the amorphous material. This difference allowed the transformation of amorphous lactose to its monohydrate form at high humidity to be studied in real time. Spectral fitting of frequency-domain data allowed kinetic data to be obtained and the crystallization was found to obey Avrami kinetics. Bulk changes during the crystallization could also be observed in the time-domain.

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Crystallization of amorphous lactose at high humidity studied by terahertz time domain spectroscopy

Abstract

Bibliographical note

ASJC Scopus subject areas

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