Cryptosporidium parvum infection requires host cell actin polymerization

DA Elliott; DJ Coleman; MA Lane; Robin May; Laura Machesky; DP Clark

doi:10.1128/IAI.69.9.5940-5942.2001

Cryptosporidium parvum infection requires host cell actin polymerization

DA Elliott, DJ Coleman, MA Lane, Robin May, Laura Machesky, DP Clark

Biosciences

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71 Citations (Scopus)

Abstract

The intracellular protozoan parasite Cryptosporidium parvum accumulates host cell actin at the interface between the parasite and the host cell cytoplasm. Here we show that the actin polymerizing proteins Arp2/3, vasodilator-stimulated phosphoprotein (VASP), and neural Wiskott Aldrich syndrome protein (N-WASP) are present at this interface and that host cell actin polymerization is necessary for parasite infection.

Original language	English
Pages (from-to)	5940-5942
Number of pages	3
Journal	Infection and Immunity
Volume	69
Issue number	9
DOIs	https://doi.org/10.1128/IAI.69.9.5940-5942.2001
Publication status	Published - 1 Sept 2001

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10.1128/IAI.69.9.5940-5942.2001

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title = "Cryptosporidium parvum infection requires host cell actin polymerization",

abstract = "The intracellular protozoan parasite Cryptosporidium parvum accumulates host cell actin at the interface between the parasite and the host cell cytoplasm. Here we show that the actin polymerizing proteins Arp2/3, vasodilator-stimulated phosphoprotein (VASP), and neural Wiskott Aldrich syndrome protein (N-WASP) are present at this interface and that host cell actin polymerization is necessary for parasite infection.",

author = "DA Elliott and DJ Coleman and MA Lane and Robin May and Laura Machesky and DP Clark",

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AU - Elliott, DA

AU - Coleman, DJ

AU - Lane, MA

AU - May, Robin

AU - Machesky, Laura

AU - Clark, DP

PY - 2001/9/1

Y1 - 2001/9/1

N2 - The intracellular protozoan parasite Cryptosporidium parvum accumulates host cell actin at the interface between the parasite and the host cell cytoplasm. Here we show that the actin polymerizing proteins Arp2/3, vasodilator-stimulated phosphoprotein (VASP), and neural Wiskott Aldrich syndrome protein (N-WASP) are present at this interface and that host cell actin polymerization is necessary for parasite infection.

AB - The intracellular protozoan parasite Cryptosporidium parvum accumulates host cell actin at the interface between the parasite and the host cell cytoplasm. Here we show that the actin polymerizing proteins Arp2/3, vasodilator-stimulated phosphoprotein (VASP), and neural Wiskott Aldrich syndrome protein (N-WASP) are present at this interface and that host cell actin polymerization is necessary for parasite infection.

U2 - 10.1128/IAI.69.9.5940-5942.2001

DO - 10.1128/IAI.69.9.5940-5942.2001

M3 - Article

C2 - 11500478

VL - 69

SP - 5940

EP - 5942

JO - Infection and Immunity

JF - Infection and Immunity

IS - 9

ER -

Cryptosporidium parvum infection requires host cell actin polymerization

Abstract

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