COVID-19 in children with haematological malignancies

Gerard Cathal Millen, Roland Arnold, Jean-Baptiste Cazier, Helen Curley, Richard Feltbower, Ashley Gamble, Adam Glaser, Richard G Grundy, Laura Kirton, Lennard Y W Lee, Martin G McCabe, Claire Palles, Bob Phillips, Charles A Stiller, Csilla Varnai, Pamela Kearns

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Abstract

Background 

Children with cancer are not at increased risk of severe SARS-CoV-2 infection; however, adults with haematological malignancies have increased risk of severe infections compared with non-haematological malignancies.

Methods 

We compared patients with haematological and non-haematological malignancies enrolled in the UK Paediatric Coronavirus Cancer Monitoring Project between 12 March 2020 and 16 February 2021. Children who received stem cell transplantation were excluded.

Results 

Only 2/62 patients with haematological malignancy had severe/critical infections, with an OR of 0.5 for patients with haematological compared with non-haematological malignancies.

Interpretation 

Children with haematological malignancies are at no greater risk of severe SARS-CoV-2 infection than those with non-haematological malignancies.

Data availability statement

Data are available on reasonable request. The database contains de-identified participant data which are anonymised at source prior to upload. Reasonable requests for data sharing will be considered.

Original languageEnglish
Pages (from-to)186-188
Number of pages3
JournalArchives of Disease in Childhood
Volume107
Issue number2
Early online date22 Jul 2021
DOIs
Publication statusPublished - 1 Feb 2022

Bibliographical note

Publisher Copyright:
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

Funding Information:
University of Birmingham provided the database and bio-informatics support, GCM is partially funded by a Cancer Research UK grant (A30259). This paper presents independent research supported by the National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre (Grant Reference Number BRC-1215-20009).

Keywords

  • Covid-19
  • Data collection
  • Epidemiology
  • COVID-19
  • epidemiology
  • data collection
  • Severity of Illness Index
  • Humans
  • Risk Factors
  • Risk Assessment/statistics & numerical data
  • Child, Preschool
  • Infant
  • Male
  • COVID-19/diagnosis
  • SARS-CoV-2/immunology
  • Adolescent
  • Hematologic Neoplasms/epidemiology
  • Female
  • Child
  • Cohort Studies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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