Cough in idiopathic pulmonary fibrosis

Mirjam J.G. Van Manen, Surinder S. Birring, Carlo Vancheri, Vincent Cottin, Elisabetta A. Renzoni, Anne Marie Russell, Marlies S. Wijsenbeek*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Many patients with idiopathic pulmonary fibrosis (IPF) complain of chronic refractory cough. Chronic cough is a distressing and disabling symptom with a major impact on quality of life. During recent years, progress has been made in gaining insight into the pathogenesis of cough in IPF, which is most probably “multifactorial” and influenced by mechanical, biochemical and neurosensory changes, with an important role for comorbidities as well. Clinical trials of cough treatment in IPF are emerging, and cough is increasingly included as a secondary end-point in trials assessing new compounds for IPF. It is important that such studies include adequate end-points to assess cough both objectively and subjectively. This article summarises the latest insights into chronic cough in IPF. It describes the different theories regarding the pathophysiology of cough, reviews the different methods to assess cough and deals with recent and future developments in the treatment of cough in IPF.

Original languageEnglish
Pages (from-to)278-286
Number of pages9
JournalEuropean Respiratory Review
Volume25
Issue number141
DOIs
Publication statusPublished - 1 Sept 2016

Bibliographical note

Publisher Copyright:
© ERS 2016.

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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