Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study

Giulia Vivaldi; David A Jolliffe; Sian Faustini; Adrian M Shields; Hayley Holt; Natalia Perdek; Mohammad Talaei; Florence Tydeman; Emma S Chambers; Weigang Cai; Wenhao Li; Joseph M Gibbons; Corinna Pade; Áine McKnight; Seif O Shaheen; Alex G Richter; Adrian R Martineau

doi:10.1093/infdis/jiac321

Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study

Giulia Vivaldi^*, David A Jolliffe, Sian Faustini, Adrian M Shields, Hayley Holt, Natalia Perdek, Mohammad Talaei, Florence Tydeman, Emma S Chambers, Weigang Cai, Wenhao Li, Joseph M Gibbons, Corinna Pade, Áine McKnight, Seif O Shaheen, Alex G Richter, Adrian R Martineau

^*Corresponding author for this work

Inflammation and Ageing

Research output: Contribution to journal › Article › peer-review

Abstract

In this population-based cohort of 7538 adults, combined immunoglobulin (Ig) G, IgA, and IgM (IgG/A/M) anti-spike titers measured after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination were predictive of protection against breakthrough SARS-CoV-2 infection. Discrimination was significantly improved by adjustment for factors influencing risk of SARS-CoV-2 exposure, including household overcrowding, public transport use, and visits to indoor public places. Anti-spike IgG/A/M titers showed positive correlation with neutralizing antibody titers (r_s = 0.80 [95% confidence interval, .72-.86]; P < .001) and S peptide-stimulated interferon-γ concentrations (r_s = 0.31 [.13-.47]; P < .001).

Original language	English
Pages (from-to)	1903-1908
Number of pages	6
Journal	The Journal of Infectious Diseases
Volume	226
Issue number	11
Early online date	30 Jul 2022
DOIs	https://doi.org/10.1093/infdis/jiac321
Publication status	Published - 1 Dec 2022

Bibliographical note

Financial support:
This work was supported by Barts Charity (grants MGU0466 to A. R. M., MGU0459 to D. A. J. and E. S. C., and MGU0558 to J. M. G. and A. M.); by the Fischer Family Trust, The Exilarch’s Foundation, and DSM Nutritional Products (donations to Queen Mary University of London); the Rosetrees Trust and The Bloom Foundation (grant M771 to M. T.); the Rosetrees Trust (grant CF1\100003 to J. M. G. and A. M.); and the John Black Charitable Foundation (grant M946 to A. M.).

Copyright:
© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Keywords

Adult
Humans
COVID-19/prevention & control
SARS-CoV-2
Longitudinal Studies
Immunologic Tests
Immunoglobulin G
Antibodies, Viral

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/infdis/jiac321

Cite this

Vivaldi, G., Jolliffe, D. A., Faustini, S., Shields, A. M., Holt, H., Perdek, N., Talaei, M., Tydeman, F., Chambers, E. S., Cai, W., Li, W., Gibbons, J. M., Pade, C., McKnight, Á., Shaheen, S. O., Richter, A. G., & Martineau, A. R. (2022). Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study. The Journal of Infectious Diseases, 226(11), 1903-1908. https://doi.org/10.1093/infdis/jiac321

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title = "Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study",

abstract = "In this population-based cohort of 7538 adults, combined immunoglobulin (Ig) G, IgA, and IgM (IgG/A/M) anti-spike titers measured after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination were predictive of protection against breakthrough SARS-CoV-2 infection. Discrimination was significantly improved by adjustment for factors influencing risk of SARS-CoV-2 exposure, including household overcrowding, public transport use, and visits to indoor public places. Anti-spike IgG/A/M titers showed positive correlation with neutralizing antibody titers (rs = 0.80 [95% confidence interval, .72-.86]; P < .001) and S peptide-stimulated interferon-γ concentrations (rs = 0.31 [.13-.47]; P < .001).",

keywords = "Adult, Humans, COVID-19/prevention & control, SARS-CoV-2, Longitudinal Studies, Immunologic Tests, Immunoglobulin G, Antibodies, Viral",

author = "Giulia Vivaldi and Jolliffe, {David A} and Sian Faustini and Shields, {Adrian M} and Hayley Holt and Natalia Perdek and Mohammad Talaei and Florence Tydeman and Chambers, {Emma S} and Weigang Cai and Wenhao Li and Gibbons, {Joseph M} and Corinna Pade and {\'A}ine McKnight and Shaheen, {Seif O} and Richter, {Alex G} and Martineau, {Adrian R}",

note = "Financial support: This work was supported by Barts Charity (grants MGU0466 to A. R. M., MGU0459 to D. A. J. and E. S. C., and MGU0558 to J. M. G. and A. M.); by the Fischer Family Trust, The Exilarch{\textquoteright}s Foundation, and DSM Nutritional Products (donations to Queen Mary University of London); the Rosetrees Trust and The Bloom Foundation (grant M771 to M. T.); the Rosetrees Trust (grant CF1\100003 to J. M. G. and A. M.); and the John Black Charitable Foundation (grant M946 to A. M.). Copyright: {\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",

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Vivaldi, G, Jolliffe, DA, Faustini, S , Shields, AM, Holt, H, Perdek, N, Talaei, M, Tydeman, F, Chambers, ES, Cai, W, Li, W, Gibbons, JM, Pade, C, McKnight, Á, Shaheen, SO, Richter, AG & Martineau, AR 2022, 'Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study', The Journal of Infectious Diseases, vol. 226, no. 11, pp. 1903-1908. https://doi.org/10.1093/infdis/jiac321

Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study. / Vivaldi, Giulia; Jolliffe, David A; Faustini, Sian et al.
In: The Journal of Infectious Diseases, Vol. 226, No. 11, 01.12.2022, p. 1903-1908.

Research output: Contribution to journal › Article › peer-review

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T1 - Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection

T2 - A Population-Based Longitudinal Study

AU - Vivaldi, Giulia

AU - Jolliffe, David A

AU - Faustini, Sian

AU - Shields, Adrian M

AU - Holt, Hayley

AU - Perdek, Natalia

AU - Talaei, Mohammad

AU - Tydeman, Florence

AU - Chambers, Emma S

AU - Cai, Weigang

AU - Li, Wenhao

AU - Gibbons, Joseph M

AU - Pade, Corinna

AU - McKnight, Áine

AU - Shaheen, Seif O

AU - Richter, Alex G

AU - Martineau, Adrian R

N1 - Financial support: This work was supported by Barts Charity (grants MGU0466 to A. R. M., MGU0459 to D. A. J. and E. S. C., and MGU0558 to J. M. G. and A. M.); by the Fischer Family Trust, The Exilarch’s Foundation, and DSM Nutritional Products (donations to Queen Mary University of London); the Rosetrees Trust and The Bloom Foundation (grant M771 to M. T.); the Rosetrees Trust (grant CF1\100003 to J. M. G. and A. M.); and the John Black Charitable Foundation (grant M946 to A. M.). Copyright: © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2022/12/1

Y1 - 2022/12/1

N2 - In this population-based cohort of 7538 adults, combined immunoglobulin (Ig) G, IgA, and IgM (IgG/A/M) anti-spike titers measured after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination were predictive of protection against breakthrough SARS-CoV-2 infection. Discrimination was significantly improved by adjustment for factors influencing risk of SARS-CoV-2 exposure, including household overcrowding, public transport use, and visits to indoor public places. Anti-spike IgG/A/M titers showed positive correlation with neutralizing antibody titers (rs = 0.80 [95% confidence interval, .72-.86]; P < .001) and S peptide-stimulated interferon-γ concentrations (rs = 0.31 [.13-.47]; P < .001).

AB - In this population-based cohort of 7538 adults, combined immunoglobulin (Ig) G, IgA, and IgM (IgG/A/M) anti-spike titers measured after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination were predictive of protection against breakthrough SARS-CoV-2 infection. Discrimination was significantly improved by adjustment for factors influencing risk of SARS-CoV-2 exposure, including household overcrowding, public transport use, and visits to indoor public places. Anti-spike IgG/A/M titers showed positive correlation with neutralizing antibody titers (rs = 0.80 [95% confidence interval, .72-.86]; P < .001) and S peptide-stimulated interferon-γ concentrations (rs = 0.31 [.13-.47]; P < .001).

KW - Adult

KW - Humans

KW - COVID-19/prevention & control

KW - SARS-CoV-2

KW - Longitudinal Studies

KW - Immunologic Tests

KW - Immunoglobulin G

KW - Antibodies, Viral

U2 - 10.1093/infdis/jiac321

DO - 10.1093/infdis/jiac321

M3 - Article

C2 - 35906930

SN - 0022-1899

VL - 226

SP - 1903

EP - 1908

JO - The Journal of Infectious Diseases

JF - The Journal of Infectious Diseases

IS - 11

ER -

Vivaldi G, Jolliffe DA, Faustini S , Shields AM, Holt H, Perdek N et al. Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study. The Journal of Infectious Diseases. 2022 Dec 1;226(11):1903-1908. Epub 2022 Jul 30. doi: 10.1093/infdis/jiac321

Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study

Abstract

Bibliographical note

Keywords

UN SDGs

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Cite this