Controlling catalyst activity, chemoselectivity and stereoselectivity with the mechanical bond

Andrew W. Heard, Jorge Meijide Suárez, Stephen M. Goldup*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)


Mechanically interlocked molecules, such as rotaxanes and catenanes, are receiving increased attention as scaffolds for the development of new catalysts, driven by both their increasing accessibility and high-profile examples of the mechanical bond delivering desirable behaviours and properties. In this Review, we survey recent advances in the catalytic applications of mechanically interlocked molecules organized by the effect of the mechanical bond on key catalytic properties, namely, activity, chemoselectivity and stereoselectivity, and focus on how the mechanically bonded structure leads to the observed behaviour. Our aim is to inspire future investigations of mechanically interlocked catalysts, including those outside of the supramolecular community. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)182-196
Number of pages15
JournalNature Reviews Chemistry
Issue number3
Early online date21 Jan 2022
Publication statusPublished - Mar 2022

Bibliographical note

Funding Information:
A.W.H. thanks the University of Southampton for a Presidential Scholarship. J.M.S. thanks the Royal Society for a Newton International Fellowship. S.M.G. thanks the European Research Council (Consolidator Grant agreement 724987) for funding. S.M.G. is a Royal Society Wolfson Research Fellow.

Publisher Copyright:
© 2022, Springer Nature Limited.

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering


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