Abstract
Ten years ago this journal published a review with an almost identical title detailing how the then recent introduction of transfection technology had advanced our understanding of the molecular control of transcriptional processes in Plasmodium falciparum, particularly in terms of promoter structure and function. In the succeeding years, sequencing of several Plasmodium spp. genomes and application of high throughput global postgenomic technologies have proven as significant, if not more, as has the ability to genetically manipulate these parasites in dissecting the molecular control of gene expression. Here we aim to review our current understanding of the control of gene expression in P. falciparum, including evidence available from other Plasmodium spp. and apicomplexan parasites. Specifically, however, we will address the current polarised debate regarding the level at which control is mediated, and attempt to identify some of the challenges this field faces in the next 10 years. Crown
| Original language | English |
|---|---|
| Pages (from-to) | 9-25 |
| Number of pages | 17 |
| Journal | Molecular and biochemical parasitology |
| Volume | 164 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Mar 2009 |
Bibliographical note
Funding Information:We would like to thank our colleagues and anonymous reviewers who provided valuable discussion as well as critical reading of this manuscript, particularly acknowledging the contribution of Sue Kyes. We also wish to acknowledge support from the Keele University Medical School (P.H., E.W., R.D.E.), the Biotechnology and Biological Sciences Research Council (K.R.) and The Royal Society (P.H.).
Keywords
- Antisense transcripts
- Bioinformatics
- Chromatin
- Epigenetics
- Malaria
- mRNA stability
- ncRNA
- Promoter
- Transcription
- Transcription factors
ASJC Scopus subject areas
- Parasitology
- Molecular Biology
