Control of breathing

Jerome A Dempsey, Joseph Welch

Research output: Contribution to journalReview articlepeer-review

Abstract

Substantial advances have been made recently into the discovery of fundamental mechanisms underlying the neural control of breathing and even some inroads into translating these findings to treating breathing disorders. Here, we review several of these advances, starting with an appreciation of the importance of V̇A:V̇CO2:PaCO2 relationships, then summarizing our current understanding of the mechanisms and neural pathways for central rhythm generation, chemoreception, exercise hyperpnea, plasticity, and sleep-state effects on ventilatory control. We apply these fundamental principles to consider the pathophysiology of ventilatory control attending hypersensitized chemoreception in select cardiorespiratory diseases, the pathogenesis of sleep-disordered breathing, and the exertional hyperventilation and dyspnea associated with aging and chronic diseases. These examples underscore the critical importance that many ventilatory control issues play in disease pathogenesis, diagnosis, and treatment.
Original languageEnglish
JournalSeminars in respiratory and critical care medicine
DOIs
Publication statusE-pub ahead of print - 11 Jul 2023

Keywords

  • chemoreception
  • exercise hyperpnea
  • plasticity
  • sleep-disordered breathing
  • respiratory rhythm generation
  • exertional dyspnea
  • COPD
  • CHF
  • aging

Fingerprint

Dive into the research topics of 'Control of breathing'. Together they form a unique fingerprint.

Cite this