TY - JOUR
T1 - Contact lens-based microchannel rings for detecting ocular hypertension
AU - Alqurashi, Yousef
AU - Elsherif, Mohamed
AU - Moreddu, Rosalia
AU - Cieslak, Magdalena
AU - Dhaliwal, Hemeth
AU - Essa, Khamis
AU - Butt, Haider
PY - 2022/10/21
Y1 - 2022/10/21
N2 - Glaucoma is a major cause of irreversible blindness worldwide. The most acknowledged biomarker to diagnose and monitor glaucoma progression is intraocular pressure (IOP). Gold standard techniques for IOP monitoring are invasive, uncomfortable, and require visiting a clinic. In addition, most methods only provide a single snapshot on widely varying parameters. On the other hand, contact lenses have attracted particular interest to be used as continuous monitoring platforms to incorporate sensors, drugs, and more. Here, commercial contact lenses were laser-processed to be capable of detecting IOP variations in the physiological range. Three ring-couples with interspaces of 1.0, 1.5, and 2.0 mm were engraved on three soft contact lenses separately by using a carbon dioxide laser. The IOP/pressure variations induced repeatable changes in the ring-couple interspace which acted as a smartphone-readable pressure sensor. The processed contact lenses may be a potential candidate toward IOP monitoring at point-of-care settings.
AB - Glaucoma is a major cause of irreversible blindness worldwide. The most acknowledged biomarker to diagnose and monitor glaucoma progression is intraocular pressure (IOP). Gold standard techniques for IOP monitoring are invasive, uncomfortable, and require visiting a clinic. In addition, most methods only provide a single snapshot on widely varying parameters. On the other hand, contact lenses have attracted particular interest to be used as continuous monitoring platforms to incorporate sensors, drugs, and more. Here, commercial contact lenses were laser-processed to be capable of detecting IOP variations in the physiological range. Three ring-couples with interspaces of 1.0, 1.5, and 2.0 mm were engraved on three soft contact lenses separately by using a carbon dioxide laser. The IOP/pressure variations induced repeatable changes in the ring-couple interspace which acted as a smartphone-readable pressure sensor. The processed contact lenses may be a potential candidate toward IOP monitoring at point-of-care settings.
KW - carbon dioxide laser
KW - contact lenses
KW - glaucoma
KW - intraocular pressure
UR - http://www.scopus.com/inward/record.url?scp=85140489250&partnerID=8YFLogxK
U2 - 10.3390/app122010661
DO - 10.3390/app122010661
M3 - Article
SN - 2076-3417
VL - 12
JO - Applied Sciences
JF - Applied Sciences
IS - 20
M1 - 10661
ER -