Collagen biomineralization in vivo by sustained release of inorganic phosphate ions

Pamela Habibovic; David Bassett; Charles J. Doillon; Catherine Gerard; Marc D. McKee; Jake E. Barralet

doi:10.1002/adma.200902778

Collagen biomineralization in vivo by sustained release of inorganic phosphate ions

Pamela Habibovic^*, David Bassett, Charles J. Doillon, Catherine Gerard, Marc D. McKee, Jake E. Barralet

^*Corresponding author for this work

Chemical Engineering

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

(Figure Presented) A new strategy for mineralized tissue formation in vivo is presented based on localized sustained delivery of inorganic orthophosphate (Pi) sufficient to supersaturate tissue surrounding an implant and induce mineralization of collagen. After 15 days implantation mineral formation around the implants was detected. Histology and electron microscopy show two populations of apatite; inter-fibrillar microcrystals and nanocrystals associated with collagen.

Original language	English
Pages (from-to)	1858-1862
Number of pages	5
Journal	Advanced Materials
Volume	22
Issue number	16
DOIs	https://doi.org/10.1002/adma.200902778
Publication status	Published - 22 Apr 2010

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.200902778

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abstract = "(Figure Presented) A new strategy for mineralized tissue formation in vivo is presented based on localized sustained delivery of inorganic orthophosphate (Pi) sufficient to supersaturate tissue surrounding an implant and induce mineralization of collagen. After 15 days implantation mineral formation around the implants was detected. Histology and electron microscopy show two populations of apatite; inter-fibrillar microcrystals and nanocrystals associated with collagen.",

author = "Pamela Habibovic and David Bassett and Doillon, {Charles J.} and Catherine Gerard and McKee, {Marc D.} and Barralet, {Jake E.}",

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AU - Habibovic, Pamela

AU - Bassett, David

AU - Doillon, Charles J.

AU - Gerard, Catherine

AU - McKee, Marc D.

AU - Barralet, Jake E.

PY - 2010/4/22

Y1 - 2010/4/22

N2 - (Figure Presented) A new strategy for mineralized tissue formation in vivo is presented based on localized sustained delivery of inorganic orthophosphate (Pi) sufficient to supersaturate tissue surrounding an implant and induce mineralization of collagen. After 15 days implantation mineral formation around the implants was detected. Histology and electron microscopy show two populations of apatite; inter-fibrillar microcrystals and nanocrystals associated with collagen.

AB - (Figure Presented) A new strategy for mineralized tissue formation in vivo is presented based on localized sustained delivery of inorganic orthophosphate (Pi) sufficient to supersaturate tissue surrounding an implant and induce mineralization of collagen. After 15 days implantation mineral formation around the implants was detected. Histology and electron microscopy show two populations of apatite; inter-fibrillar microcrystals and nanocrystals associated with collagen.

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U2 - 10.1002/adma.200902778

DO - 10.1002/adma.200902778

M3 - Article

SN - 0935-9648

VL - 22

SP - 1858

EP - 1862

JO - Advanced Materials

JF - Advanced Materials

IS - 16

ER -

Collagen biomineralization in vivo by sustained release of inorganic phosphate ions

Abstract

ASJC Scopus subject areas

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