Cohort study of anticoagulation self-monitoring (CASM): A prospective study of its effectiveness in the community

Alison Ward*, Alice Tompson, David Fitzmaurice, Stephen Sutton, Rafael Perera, Carl Heneghan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Background Trials show that oral anticoagulation therapy (OAT) substantially reduces thromboembolic events without an increase in major haemorrhagic events, but it is not known whether these results translate into routine practice. Aim To estimate the current levels of control and adverse events in patients self-monitoring OAT, explore the factors that predict success, and determine whether the level of side effects reported from randomised controlled trials are translated to a non-selected population. Design and setting Prospective cohort study in the UK. Method Participants were aged ≤18 years and registered with a GP. Main outcomes were the proportion of participants, over 12 months, who were still self-monitoring, had not experienced adverse events, and had achieved 80% of time in therapeutic range (TTR). Results In total, 296 participants were recruited their median age was 61 years and 55.1% were male. Participants were predominately professional or held a university qualification (82.7%). At 12 months, 267 (90.2%) were still self-monitoring. Mean TTR was 75.3% (standard deviation 16.9).Six serious and two minor adverse events were reported by GPS. Only 45.9% of participants received any in-person training at the outset. Increased age (P = 0.027), general wellbeing (EQ-5D visual score, P = 0.020), and lower target international normalised range (INR, P = 0.032) were all associated with high (

Original languageEnglish
Pages (from-to)e428-e437
JournalBritish Journal of General Practice
Volume65
Issue number636
DOIs
Publication statusPublished - 1 Jul 2015

Keywords

  • Anticoagulants
  • Monitoring
  • Primary care
  • Self-monitoring
  • Selfmanagement

ASJC Scopus subject areas

  • Family Practice

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