Cobalt ferrite nanoparticle’s safety in biomedical and agricultural applications: a review of recent progress

Md Salman Shakil, Md Simul Bhuiya, Md Reaz Morshed, Golap Babu, Mahruba Sultana Niloy, Md Sakib Hossen, Md Asiful Islam

Research output: Contribution to journalReview articlepeer-review


Cobalt ferrite nanoparticles (CFN) have drawn attention as a theranostic agent. Unique physicochemical features of CFN and magnetic properties make CFN an outstanding candidate for biomedical, agricultural, and environmental applications. The extensive use of CFN may result in intentional inoculation of humans for disease diagnosis and therapeutic purposes or unintentional penetration of CFN via inhalation, ingestion, adsorption, or other means. Therefore, understanding the potential cytotoxicity of CFN may pave the way for their future biomedical and agricultural applications. This review scrutinized CFN biocompatibility, possible effects, and cytotoxic mechanisms in different biological systems. Literature indicates CFN toxicity is linked with their size, synthesizing methods, coating materials, exposure time, route of administration, and test concentrations. Some in vitro cytotoxicity tests showed misleading results of CFN potency; this might be due to the interaction of CFN with cytotoxicity assay regents. To date, published research indicates that the biocompatibility of CFN outweighed its cytotoxic effects in plant or animal models, but the opposite outcomes were observed in aquatic Zebrafish.
Original languageEnglish
Pages (from-to)1756-1775
Number of pages20
JournalCurrent medicinal chemistry
Issue number15
Early online date30 Dec 2022
Publication statusPublished - May 2023


Dive into the research topics of 'Cobalt ferrite nanoparticle’s safety in biomedical and agricultural applications: a review of recent progress'. Together they form a unique fingerprint.

Cite this