Co-ordination of intrathymic self-representation

Graham Anderson; William E Jenkinson

doi:10.1038/ni.3251

Co-ordination of intrathymic self-representation

Graham Anderson, William E Jenkinson

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Intrathymic expression of self antigens is key for central tolerance. RNA-sequencing analysis of tissue-restricted antigens in individual medullary thymic epithelial cells reveals co-ordination in the gene-expression patterns that ensures effective self-representation for the production of self-tolerant T cells.

Original language	English
Pages (from-to)	895-896
Number of pages	2
Journal	Nature Immunology
Volume	16
Issue number	9
Early online date	19 Aug 2015
DOIs	https://doi.org/10.1038/ni.3251
Publication status	Published - Sept 2015

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Role of the Lymphotoxin signaling axis in the regulation of thymic microenvironments:Implications for age-associated thymic atrophy
Jenkinson, W. (Principal Investigator)
Biotechnology & Biological Sciences Research Council
1/05/15 → 30/04/18
Project: Research Councils

Cite this

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title = "Co-ordination of intrathymic self-representation",

abstract = "Intrathymic expression of self antigens is key for central tolerance. RNA-sequencing analysis of tissue-restricted antigens in individual medullary thymic epithelial cells reveals co-ordination in the gene-expression patterns that ensures effective self-representation for the production of self-tolerant T cells.",

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Co-ordination of intrathymic self-representation

Abstract

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Role of the Lymphotoxin signaling axis in the regulation of thymic microenvironments:Implications for age-associated thymic atrophy

Cite this