Chronic myeloid leukaemia as a model of disease evolution in human cancer

Junia V Melo; David J Barnes

doi:10.1038/nrc2147

Chronic myeloid leukaemia as a model of disease evolution in human cancer

Junia V Melo, David J Barnes

Cancer and Genomic Sciences

Research output: Contribution to journal › Review article › peer-review

Abstract

Chronic myeloid leukaemia (CML) can be considered as a paradigm for neoplasias that evolve through a multi-step process. CML is also one of the best examples of a disease that can be targeted by molecular therapy; however, the success of new 'designer drugs' is largely restricted to the chronic phase of the disease. If not cured at this stage, CML invariably progresses and transforms into an acute-type leukaemia undergoing a 'blast crisis'. The causes of this transformation are still poorly understood. What mechanisms underlie this progression, and are they shared by other common cancers?

Original language	English
Pages (from-to)	441-53
Number of pages	13
Journal	Nature Reviews Cancer
Volume	7
Issue number	6
DOIs	https://doi.org/10.1038/nrc2147
Publication status	Published - Jun 2007

Keywords

Animals
Blast Crisis
Cell Differentiation
Disease Progression
Fusion Proteins, bcr-abl/physiology
Gene Expression Profiling
Genes, Tumor Suppressor/physiology
Genomic Instability
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics
Models, Biological
Neoplasms/pathology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nrc2147

Cite this

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title = "Chronic myeloid leukaemia as a model of disease evolution in human cancer",

abstract = "Chronic myeloid leukaemia (CML) can be considered as a paradigm for neoplasias that evolve through a multi-step process. CML is also one of the best examples of a disease that can be targeted by molecular therapy; however, the success of new 'designer drugs' is largely restricted to the chronic phase of the disease. If not cured at this stage, CML invariably progresses and transforms into an acute-type leukaemia undergoing a 'blast crisis'. The causes of this transformation are still poorly understood. What mechanisms underlie this progression, and are they shared by other common cancers?",

keywords = "Animals, Blast Crisis, Cell Differentiation, Disease Progression, Fusion Proteins, bcr-abl/physiology, Gene Expression Profiling, Genes, Tumor Suppressor/physiology, Genomic Instability, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics, Models, Biological, Neoplasms/pathology",

author = "Melo, {Junia V} and Barnes, {David J}",

year = "2007",

month = jun,

doi = "10.1038/nrc2147",

language = "English",

volume = "7",

pages = "441--53",

journal = "Nature Reviews Cancer",

issn = "1474-175X",

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AU - Melo, Junia V

AU - Barnes, David J

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AB - Chronic myeloid leukaemia (CML) can be considered as a paradigm for neoplasias that evolve through a multi-step process. CML is also one of the best examples of a disease that can be targeted by molecular therapy; however, the success of new 'designer drugs' is largely restricted to the chronic phase of the disease. If not cured at this stage, CML invariably progresses and transforms into an acute-type leukaemia undergoing a 'blast crisis'. The causes of this transformation are still poorly understood. What mechanisms underlie this progression, and are they shared by other common cancers?

KW - Animals

KW - Blast Crisis

KW - Cell Differentiation

KW - Disease Progression

KW - Fusion Proteins, bcr-abl/physiology

KW - Gene Expression Profiling

KW - Genes, Tumor Suppressor/physiology

KW - Genomic Instability

KW - Humans

KW - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics

KW - Models, Biological

KW - Neoplasms/pathology

U2 - 10.1038/nrc2147

DO - 10.1038/nrc2147

M3 - Review article

C2 - 17522713

SN - 1474-175X

VL - 7

SP - 441

EP - 453

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 6

ER -

Chronic myeloid leukaemia as a model of disease evolution in human cancer

Abstract

Keywords

UN SDGs

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