Chronic myeloid leukaemia as a model of disease evolution in human cancer

Junia V Melo, David J Barnes

Research output: Contribution to journalReview articlepeer-review


Chronic myeloid leukaemia (CML) can be considered as a paradigm for neoplasias that evolve through a multi-step process. CML is also one of the best examples of a disease that can be targeted by molecular therapy; however, the success of new 'designer drugs' is largely restricted to the chronic phase of the disease. If not cured at this stage, CML invariably progresses and transforms into an acute-type leukaemia undergoing a 'blast crisis'. The causes of this transformation are still poorly understood. What mechanisms underlie this progression, and are they shared by other common cancers?

Original languageEnglish
Pages (from-to)441-53
Number of pages13
JournalNature Reviews Cancer
Issue number6
Publication statusPublished - Jun 2007


  • Animals
  • Blast Crisis
  • Cell Differentiation
  • Disease Progression
  • Fusion Proteins, bcr-abl/physiology
  • Gene Expression Profiling
  • Genes, Tumor Suppressor/physiology
  • Genomic Instability
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics
  • Models, Biological
  • Neoplasms/pathology


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