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Abstract
The inefficacy of antibiotics against Gram-negative bacteria is a major challenge for treatment of many clinically important bacterial infections. The complex structure of the double cell membrane of Gram-negative bacteria makes it inaccessible to many key antibiotics such as vancomycin and also presents a major challenge for drug development. In this study we design of a novel hybrid silica nanoparticle system bearing membrane targeting groups with the antibiotic encapsulated together with a ruthenium luminescent tracking agent, for optical detection of the nanoparticle delivery in the bacterial cell. The hybrid system shows delivery of vancomycin and efficacy against a library of Gram negative bacterial species. Evidence of penetration of nanoparticles in bacteria cells is achieved via luminescence of the ruthenium signal. Our studies show that nanoparticles modified with aminopolycarboxylate chelating groups are an effective delivery system in bacterial growth inhibition in species whereas the molecular antibiotic is ineffective. This design provides a new platform for delivery of antibiotics that cannot alone penetrate the bacterial membrane.
Original language | English |
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Pages (from-to) | 2453-2461 |
Number of pages | 9 |
Journal | Nanoscale Advances |
Volume | 5 |
Issue number | 9 |
Early online date | 20 Feb 2023 |
DOIs | |
Publication status | Published - 7 May 2023 |
Bibliographical note
This journal is © The Royal Society of Chemistry.Fingerprint
Dive into the research topics of 'Chelating silica nanoparticles for efficient antibiotic delivery and particle imaging in Gram-negative bacteria'. Together they form a unique fingerprint.Projects
- 1 Finished
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Targeting Periplasmic Adaptor Proteins to Improve Efficacy
Biotechnology & Biological Sciences Research Council
3/08/15 → 28/02/21
Project: Research Councils