Projects per year
The ability of chaperonins to buffer mutations that affect protein folding pathways suggests that their abundance should be evolutionarily advantageous. Here, we investigate the effect of chaperonin overproduction on cellular fitness in Escherichia coli. We demonstrate that chaperonin abundance confers 1) an ability to tolerate higher temperatures, 2) improved cellular fitness, and 3) enhanced folding of metabolic enzymes, which is expected to lead to enhanced energy harvesting potential.
|Journal||Frontiers in Molecular Bioscience|
|Publication status||Published - 26 Jul 2021|
Bibliographical noteCopyright © 2021 Kumar, Chugh, Dutta, Mahamkali, Bose, Mande, Mande and Lund.
- competitive index
- metabolic flux
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- 1 Finished
A zebrafish model to study the role of chaperonins in Mycobacterial infection
Biotechnology & Biological Sciences Research Council
1/05/19 → 31/08/22
Project: Research Councils