Chaperonin Abundance Enhances Bacterial Fitness

C M Santosh Kumar, Kritika Chugh, Anirban Dutta, Vishnuvardhan Mahamkali, Tungadri Bose, Sharmila S Mande, Shekhar C Mande, Peter A Lund

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The ability of chaperonins to buffer mutations that affect protein folding pathways suggests that their abundance should be evolutionarily advantageous. Here, we investigate the effect of chaperonin overproduction on cellular fitness in Escherichia coli. We demonstrate that chaperonin abundance confers 1) an ability to tolerate higher temperatures, 2) improved cellular fitness, and 3) enhanced folding of metabolic enzymes, which is expected to lead to enhanced energy harvesting potential.

Original languageEnglish
Article number669996
JournalFrontiers in Molecular Bioscience
Publication statusPublished - 26 Jul 2021

Bibliographical note

Copyright © 2021 Kumar, Chugh, Dutta, Mahamkali, Bose, Mande, Mande and Lund.


  • GroEL
  • competitive index
  • evolution
  • metabolic flux
  • metabolism
  • proteomics


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