Challenging our understanding of B-cell lymphomagenesis and risk: Paediatric high-grade B-cell lymphoma, not otherwise specified with a DDX3X::MLLT10 fusion and an IGH deletion

Genomics England Research Consortium; Lucy Hare; Jamie Trotman; Patrick Tarpey; Elizabeth Hook; G. A.Amos Burke

doi:10.1002/pbc.30810

Challenging our understanding of B-cell lymphomagenesis and risk: Paediatric high-grade B-cell lymphoma, not otherwise specified with a DDX3X::MLLT10 fusion and an IGH deletion

Genomics England Research Consortium, Lucy Hare, Jamie Trotman, Patrick Tarpey, Elizabeth Hook, G. A.Amos Burke^*

^*Corresponding author for this work

Cancer and Genomic Sciences

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Abstract

We report a unique case of high-grade B-cell lymphoma, not otherwise specified in a 5-year-old child. Whole-genome sequencing revealed a DDX3X::MLLT10 fusion, usually seen in T-cell acute lymphoblastic leukaemia (ALL). This suggests the novel idea that MLLT10 fusions are capable of driving B-cell malignancies. An IGH deletion usually only seen in adults was also found. These unique genetic findings provide novel insights into B-cell lymphomagenesis. The child remains in remission 7 year post chemotherapy, which demonstrates that novel complex molecular findings do not always denote high-risk disease.

Original language	English
Journal	Pediatric Blood and Cancer
Early online date	16 Dec 2023
DOIs	https://doi.org/10.1002/pbc.30810
Publication status	E-pub ahead of print - 16 Dec 2023

Bibliographical note

Funding Information:
Lucy Hare is supported with funding from a Cancer Research UK Cambridge Centre clinical research fellowship (grant number: C9685/A25117).

Publisher Copyright:
© 2023 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.

Keywords

HGBL
lymphoma
MLLT10
NOS

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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Genomics England Research Consortium, Hare, L., Trotman, J., Tarpey, P., Hook, E., & Burke, G. A. A. (2023). Challenging our understanding of B-cell lymphomagenesis and risk: Paediatric high-grade B-cell lymphoma, not otherwise specified with a DDX3X::MLLT10 fusion and an IGH deletion. Pediatric Blood and Cancer. Advance online publication. https://doi.org/10.1002/pbc.30810

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abstract = "We report a unique case of high-grade B-cell lymphoma, not otherwise specified in a 5-year-old child. Whole-genome sequencing revealed a DDX3X::MLLT10 fusion, usually seen in T-cell acute lymphoblastic leukaemia (ALL). This suggests the novel idea that MLLT10 fusions are capable of driving B-cell malignancies. An IGH deletion usually only seen in adults was also found. These unique genetic findings provide novel insights into B-cell lymphomagenesis. The child remains in remission 7 year post chemotherapy, which demonstrates that novel complex molecular findings do not always denote high-risk disease.",

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note = "Funding Information: Lucy Hare is supported with funding from a Cancer Research UK Cambridge Centre clinical research fellowship (grant number: C9685/A25117). Publisher Copyright: {\textcopyright} 2023 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.",

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AU - Hare, Lucy

AU - Trotman, Jamie

AU - Tarpey, Patrick

AU - Hook, Elizabeth

AU - Burke, G. A.Amos

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Challenging our understanding of B-cell lymphomagenesis and risk: Paediatric high-grade B-cell lymphoma, not otherwise specified with a DDX3X::MLLT10 fusion and an IGH deletion

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this