Abstract
We report a unique case of high-grade B-cell lymphoma, not otherwise specified in a 5-year-old child. Whole-genome sequencing revealed a DDX3X::MLLT10 fusion, usually seen in T-cell acute lymphoblastic leukaemia (ALL). This suggests the novel idea that MLLT10 fusions are capable of driving B-cell malignancies. An IGH deletion usually only seen in adults was also found. These unique genetic findings provide novel insights into B-cell lymphomagenesis. The child remains in remission 7 year post chemotherapy, which demonstrates that novel complex molecular findings do not always denote high-risk disease.
Original language | English |
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Journal | Pediatric Blood and Cancer |
Early online date | 16 Dec 2023 |
DOIs | |
Publication status | E-pub ahead of print - 16 Dec 2023 |
Bibliographical note
Funding Information:Lucy Hare is supported with funding from a Cancer Research UK Cambridge Centre clinical research fellowship (grant number: C9685/A25117).
Publisher Copyright:
© 2023 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.
Keywords
- HGBL
- lymphoma
- MLLT10
- NOS
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Hematology
- Oncology