Cerebral pressure-flow relationship in lowlanders and natives at high altitude

Jonathan D. Smirl; Samuel Lucas; Nia C. S. Lewis; Gregory R. duManior; Kurt J. Smith; Akke Bakker; Aperna S. Basnyat; Philip N. Ainslie

doi:10.1038/jcbfm.2013.178

Cerebral pressure-flow relationship in lowlanders and natives at high altitude

Jonathan D. Smirl, Samuel Lucas, Nia C. S. Lewis, Gregory R. duManior, Kurt J. Smith, Akke Bakker, Aperna S. Basnyat, Philip N. Ainslie

Sport, Exercise and Rehabilitation Sciences

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

We investigated if dynamic cerebral pressure-flow relationships in lowlanders are altered at high altitude (HA), differ in HA natives and after return to sea level (SL). Lowlanders were tested at SL (n=16), arrival to 5,050 m, after 2-week acclimatization (with and without end-tidal PO2 normalization), and upon SL return. High-altitude natives (n=16) were tested at 5,050 m. Testing sessions involved resting spontaneous and driven (squat-stand maneuvers at very low (VLF, 0.05 Hz) and low (LF, 0.10 Hz) frequencies) measures to maximize blood pressure (BP) variability and improve assessment of the pressure-flow relationship using transfer function analysis (TFA). Blood flow velocity was assessed in the middle (MCAv) and posterior (PCAv) cerebral arteries. Spontaneous VLF and LF phases were reduced and coherence was elevated with acclimatization to HA (P

Original language	English
Pages (from-to)	248-57
Number of pages	10
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	34
Issue number	2
Early online date	30 Oct 2013
DOIs	https://doi.org/10.1038/jcbfm.2013.178
Publication status	Published - 1 Feb 2014

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title = "Cerebral pressure-flow relationship in lowlanders and natives at high altitude",

abstract = "We investigated if dynamic cerebral pressure-flow relationships in lowlanders are altered at high altitude (HA), differ in HA natives and after return to sea level (SL). Lowlanders were tested at SL (n=16), arrival to 5,050 m, after 2-week acclimatization (with and without end-tidal PO2 normalization), and upon SL return. High-altitude natives (n=16) were tested at 5,050 m. Testing sessions involved resting spontaneous and driven (squat-stand maneuvers at very low (VLF, 0.05 Hz) and low (LF, 0.10 Hz) frequencies) measures to maximize blood pressure (BP) variability and improve assessment of the pressure-flow relationship using transfer function analysis (TFA). Blood flow velocity was assessed in the middle (MCAv) and posterior (PCAv) cerebral arteries. Spontaneous VLF and LF phases were reduced and coherence was elevated with acclimatization to HA (P",

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AU - Smirl, Jonathan D.

AU - Lucas, Samuel

AU - Lewis, Nia C. S.

AU - duManior, Gregory R.

AU - Smith, Kurt J.

AU - Bakker, Akke

AU - Basnyat, Aperna S.

AU - Ainslie, Philip N.

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AB - We investigated if dynamic cerebral pressure-flow relationships in lowlanders are altered at high altitude (HA), differ in HA natives and after return to sea level (SL). Lowlanders were tested at SL (n=16), arrival to 5,050 m, after 2-week acclimatization (with and without end-tidal PO2 normalization), and upon SL return. High-altitude natives (n=16) were tested at 5,050 m. Testing sessions involved resting spontaneous and driven (squat-stand maneuvers at very low (VLF, 0.05 Hz) and low (LF, 0.10 Hz) frequencies) measures to maximize blood pressure (BP) variability and improve assessment of the pressure-flow relationship using transfer function analysis (TFA). Blood flow velocity was assessed in the middle (MCAv) and posterior (PCAv) cerebral arteries. Spontaneous VLF and LF phases were reduced and coherence was elevated with acclimatization to HA (P

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JF - Journal of Cerebral Blood Flow and Metabolism

IS - 2

ER -

Cerebral pressure-flow relationship in lowlanders and natives at high altitude

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