CDK inhibitor p18INK4c is required for the generation of functional plasma cells

MR Tourigny, J Ursini-Siegel, H Lee, Kai-Michael Toellner, Adam Cunningham, DS Franklin, S Ely, M Chen, XF Qin, Y Xiong, Ian MacLennan, S Chen-Kiang

Research output: Contribution to journalArticle

79 Citations (Scopus)


B cell terminal differentiation is associated with the onset of high-level antibody secretion and cell cycle arrest. Here the cyclin-dependent kinase (CDK) inhibitor p18(INK4c) is shown to be required within B cells for both terminating cell proliferation and differentiation of functional plasma cells. In its absence, B cells hyperproliferate in germinal centers and extrafollicular foci in response to T-dependent antigens but serum antibody titers are severely reduced, despite unimpaired germinal center formation, class switch recombination, variable region-directed hypermutation, and differentiation to antibody-containing plasmacytoid cells. The novel link between cell cycle control and plasma cell differentiation may, at least in part, relate to p18(INK4c) inhibition of CDK6. Cell cycle arrest mediated by p18(INK4C) is therefore requisite for the generation of functional plasma cells.
Original languageEnglish
Pages (from-to)179-89
Number of pages11
Publication statusPublished - 1 Jan 2002


Dive into the research topics of 'CDK inhibitor p18INK4c is required for the generation of functional plasma cells'. Together they form a unique fingerprint.

Cite this