CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration

Siân Lax; Ewan A. Ross; Andrea White; Jennifer L. Marshall; William E. Jenkinson; Clare M. Isacke; David L. Huso; Adam F. Cunningham; Graham Anderson; Christopher D. Buckley

doi:10.1016/j.fob.2012.07.003

CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration

Siân Lax, Ewan A. Ross, Andrea White, Jennifer L. Marshall, William E. Jenkinson, Clare M. Isacke, David L. Huso, Adam F. Cunningham, Graham Anderson, Christopher D. Buckley

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

317 Downloads (Pure)

Abstract

The role of mesenchymal stromal cells (MSCs) in regulating immune responses in the thymus is currently unclear. Here we report the existence and role of a MSC population in the thymus that expresses the pericyte and MSC marker CD248 (endosialin). We show using a CD248-deficient mouse model, that CD248 expression on these cells is required for full post-natal thymus development and regeneration post-Salmonella infection. In CD248−/− mice the thymus is hypocellular and regeneration is poorer, with significant loss of all thymocyte populations. This identifies the requirement of CD248 to maintain optimal thymic cellularity post-partum and infection.

Original language	English
Pages (from-to)	187-190
Number of pages	4
Journal	FEBS Open Bio
Volume	2
Early online date	20 Jul 2012
DOIs	https://doi.org/10.1016/j.fob.2012.07.003
Publication status	Published - 2012

Keywords

CD248
Endosialin
MSC
Thymus

Access to Document

10.1016/j.fob.2012.07.003

Buckley_CD248_expression_mesenchymal_FEBS_Open_Bio_2012
Eligibility for repository : checked 26/06/2014
Final published version, 994 KBLicence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

Cortical Thymic Epithelium: Defining Developmental Pathways and Specialisation for Positive Selection
Jenkinson, W. (Principal Investigator)
Medical Research Council
3/01/11 → 2/01/14
Project: Research Councils
MRC Centre For Immune Regulation (Linked to DCDF.RRAK10540) (Linked to 14810 & 14835)
Jenkinson, E. (Principal Investigator)
Medical Research Council
3/08/09 → 30/09/17
Project: Research Councils

Cite this

@article{7d1a4596c80047c0bb597d0518d4226f,

title = "CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration",

abstract = "The role of mesenchymal stromal cells (MSCs) in regulating immune responses in the thymus is currently unclear. Here we report the existence and role of a MSC population in the thymus that expresses the pericyte and MSC marker CD248 (endosialin). We show using a CD248-deficient mouse model, that CD248 expression on these cells is required for full post-natal thymus development and regeneration post-Salmonella infection. In CD248−/− mice the thymus is hypocellular and regeneration is poorer, with significant loss of all thymocyte populations. This identifies the requirement of CD248 to maintain optimal thymic cellularity post-partum and infection.",

keywords = "CD248, Endosialin, MSC, Thymus",

author = "Si{\^a}n Lax and Ross, {Ewan A.} and Andrea White and Marshall, {Jennifer L.} and Jenkinson, {William E.} and Isacke, {Clare M.} and Huso, {David L.} and Cunningham, {Adam F.} and Graham Anderson and Buckley, {Christopher D.}",

year = "2012",

doi = "10.1016/j.fob.2012.07.003",

language = "English",

volume = "2",

pages = "187--190",

journal = "FEBS Open Bio",

issn = "2211-5463",

publisher = "Elsevier",

}

TY - JOUR

T1 - CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration

AU - Lax, Siân

AU - Ross, Ewan A.

AU - White, Andrea

AU - Marshall, Jennifer L.

AU - Jenkinson, William E.

AU - Isacke, Clare M.

AU - Huso, David L.

AU - Cunningham, Adam F.

AU - Anderson, Graham

AU - Buckley, Christopher D.

PY - 2012

Y1 - 2012

N2 - The role of mesenchymal stromal cells (MSCs) in regulating immune responses in the thymus is currently unclear. Here we report the existence and role of a MSC population in the thymus that expresses the pericyte and MSC marker CD248 (endosialin). We show using a CD248-deficient mouse model, that CD248 expression on these cells is required for full post-natal thymus development and regeneration post-Salmonella infection. In CD248−/− mice the thymus is hypocellular and regeneration is poorer, with significant loss of all thymocyte populations. This identifies the requirement of CD248 to maintain optimal thymic cellularity post-partum and infection.

AB - The role of mesenchymal stromal cells (MSCs) in regulating immune responses in the thymus is currently unclear. Here we report the existence and role of a MSC population in the thymus that expresses the pericyte and MSC marker CD248 (endosialin). We show using a CD248-deficient mouse model, that CD248 expression on these cells is required for full post-natal thymus development and regeneration post-Salmonella infection. In CD248−/− mice the thymus is hypocellular and regeneration is poorer, with significant loss of all thymocyte populations. This identifies the requirement of CD248 to maintain optimal thymic cellularity post-partum and infection.

KW - CD248

KW - Endosialin

KW - MSC

KW - Thymus

U2 - 10.1016/j.fob.2012.07.003

DO - 10.1016/j.fob.2012.07.003

M3 - Article

C2 - 23650598

SN - 2211-5463

VL - 2

SP - 187

EP - 190

JO - FEBS Open Bio

JF - FEBS Open Bio

ER -

CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration

Abstract

Keywords

Access to Document

Fingerprint

Projects

Cortical Thymic Epithelium: Defining Developmental Pathways and Specialisation for Positive Selection

MRC Centre For Immune Regulation (Linked to DCDF.RRAK10540) (Linked to 14810 & 14835)

Cite this