TY - JOUR
T1 - Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
AU - Pryce, G
AU - Ahmed, Zubair
AU - Hankey, DJR
AU - Jackson, SJ
AU - Croxford, JL
AU - Pocock, JM
AU - Ledent, C
AU - Petzold, A
AU - Thompson, AJ
AU - Giovannoni, G
AU - Cuzner, ML
AU - Baker, D
PY - 2003/6/23
Y1 - 2003/6/23
N2 - Multiple sclerosis is increasingly being recognized as a neurodegenerative disease that is triggered by inflammatory attack of the CNS. As yet there is no satisfactory treatment. Using experimental allergic encephalo myelitis (EAE), an animal model of multiple sclerosis, we demonstrate that the cannabinoid system is neuroprotective during EAE. Mice deficient in the cannabinoid receptor CB1 tolerate inflammatory and excitotoxic insults poorly and develop substantial neurodegeneration following immune attack in EAE. In addition, exogenous CB1 agonists can provide significant neuroprotection from the consequences of inflammatory CNS disease in an experimental allergic uveitis model. Therefore, in addition to symptom management, cannabis may also slow the neurodegenerative processes that ultimately lead to chronic disability in multiple sclerosis and probably other diseases.
AB - Multiple sclerosis is increasingly being recognized as a neurodegenerative disease that is triggered by inflammatory attack of the CNS. As yet there is no satisfactory treatment. Using experimental allergic encephalo myelitis (EAE), an animal model of multiple sclerosis, we demonstrate that the cannabinoid system is neuroprotective during EAE. Mice deficient in the cannabinoid receptor CB1 tolerate inflammatory and excitotoxic insults poorly and develop substantial neurodegeneration following immune attack in EAE. In addition, exogenous CB1 agonists can provide significant neuroprotection from the consequences of inflammatory CNS disease in an experimental allergic uveitis model. Therefore, in addition to symptom management, cannabis may also slow the neurodegenerative processes that ultimately lead to chronic disability in multiple sclerosis and probably other diseases.
UR - http://www.scopus.com/inward/record.url?scp=0242304878&partnerID=8YFLogxK
U2 - 10.1093/brain/awg224
DO - 10.1093/brain/awg224
M3 - Article
C2 - 12876144
SN - 1460-2156
SN - 1460-2156
SN - 1460-2156
SN - 1460-2156
SN - 1460-2156
SN - 1460-2156
SN - 1460-2156
SN - 1460-2156
SN - 1460-2156
SN - 1460-2156
SN - 1460-2156
SN - 1460-2156
SN - 1460-2156
SN - 1460-2156
SN - 1460-2156
SN - 1460-2156
SN - 1460-2156
SN - 1460-2156
SN - 1460-2156
SN - 1460-2156
VL - 126
SP - 2191
EP - 2202
JO - Brain
JF - Brain
ER -