TY - JOUR
T1 - Cancer as a risk factor for urinary tract calculi
T2 - a retrospective cohort study using ‘The Health Improvement Network’
AU - Mittal, Ankush
AU - Hassan, Motaz
AU - Chandan, Joht Singh
AU - Willis, Brian H
AU - Nirantharakumar, Krishnarajah
AU - Subramonian, Kesvapilla
PY - 2019/12
Y1 - 2019/12
N2 - Purpose: Urolithiasis is a common condition that poses significant morbidity to patients. There are similarities in the development of certain cancers and urinary tract calculi (UTC), however, little is known about their temporal relationship. This study aims to identify if cancer is a risk factor for the development of UTC. Methods: A population-based retrospective cohort study was conducted for the period 1st January 1990 to 1st May 2016. 124,901 exposed patients identified using clinical codes with newly diagnosed cancer were matched to 476,203 unexposed controls by age, gender, BMI, and general practice. The main outcome measure was the risk of developing UTC described by hazard ratios. Results: There were 512 incident UTC events in the cancer group compared to 1787 in the unexposed controls. This translated to an adjusted hazard ratio of 1.26 (95% CI 1.14–1.39; p < 0.001). A sub-analysis assessing cancer-specific effects demonstrated increased risks for 10 out of 12 common cancers, most significantly in bladder, colorectal and prostate cancer. Conclusion: This study demonstrated a 26% increased risk of UTC in cancer patients suggesting wider recognition of this risk amongst clinicians could improve diagnosis and prevention of UTC, as well as encourage further research exploring this association.
AB - Purpose: Urolithiasis is a common condition that poses significant morbidity to patients. There are similarities in the development of certain cancers and urinary tract calculi (UTC), however, little is known about their temporal relationship. This study aims to identify if cancer is a risk factor for the development of UTC. Methods: A population-based retrospective cohort study was conducted for the period 1st January 1990 to 1st May 2016. 124,901 exposed patients identified using clinical codes with newly diagnosed cancer were matched to 476,203 unexposed controls by age, gender, BMI, and general practice. The main outcome measure was the risk of developing UTC described by hazard ratios. Results: There were 512 incident UTC events in the cancer group compared to 1787 in the unexposed controls. This translated to an adjusted hazard ratio of 1.26 (95% CI 1.14–1.39; p < 0.001). A sub-analysis assessing cancer-specific effects demonstrated increased risks for 10 out of 12 common cancers, most significantly in bladder, colorectal and prostate cancer. Conclusion: This study demonstrated a 26% increased risk of UTC in cancer patients suggesting wider recognition of this risk amongst clinicians could improve diagnosis and prevention of UTC, as well as encourage further research exploring this association.
KW - Calculus
KW - Cancer
KW - Cohort
KW - Risk
KW - Stone
KW - Urinary
KW - Urolithiasis
UR - http://www.scopus.com/inward/record.url?scp=85063132951&partnerID=8YFLogxK
U2 - 10.1007/s00240-019-01127-z
DO - 10.1007/s00240-019-01127-z
M3 - Article
SN - 2194-7228
VL - 47
SP - 541
EP - 547
JO - Urolithiasis
JF - Urolithiasis
IS - 6
ER -
