TY - JOUR
T1 - Birth weight and creatinine clearance in young adult twins: influence of genetic, prenatal, and maternal factors
AU - Gielen, M
AU - Pinto-Sietsma, SJ
AU - Zeegers, Maurice
AU - Loos, RJ
AU - Fagard, R
AU - de Leeuw, PW
AU - Beunen, G
AU - Derom, C
AU - Vlietinck, R
PY - 2005/6/29
Y1 - 2005/6/29
N2 - Previous studies have shown that low birth weight (LBW) is a risk factor for renal impairment in adult life. The effects of LBW and renal function were studied by using twins, which allows distinguishing among fetoplacental, maternal, and genetic influences. Perinatal data were obtained at birth, and absolute creatinine clearance (not corrected for body surface area) was measured at a mean age of 25.6 yr in 653 individuals. Twins were considered both as individuals and as members of twin pairs. Statistical analyses were performed with and without adjusting for gestational age, zygosity, gender, age, body mass index, glucose level, BP, and smoking status. Creatinine clearance was 4 ml/min lower in twins with LBW (
AB - Previous studies have shown that low birth weight (LBW) is a risk factor for renal impairment in adult life. The effects of LBW and renal function were studied by using twins, which allows distinguishing among fetoplacental, maternal, and genetic influences. Perinatal data were obtained at birth, and absolute creatinine clearance (not corrected for body surface area) was measured at a mean age of 25.6 yr in 653 individuals. Twins were considered both as individuals and as members of twin pairs. Statistical analyses were performed with and without adjusting for gestational age, zygosity, gender, age, body mass index, glucose level, BP, and smoking status. Creatinine clearance was 4 ml/min lower in twins with LBW (
UR - http://www.scopus.com/inward/record.url?scp=28444489995&partnerID=8YFLogxK
U2 - 10.1681/ASN.2004030210
DO - 10.1681/ASN.2004030210
M3 - Article
C2 - 15944342
SN - 1533-3450
VL - 16
SP - 2471
EP - 2476
JO - Journal of the American Society of Nephrology
JF - Journal of the American Society of Nephrology
ER -