Biomarkers of endothelial dysfunction are elevated and related to prognosis in chronic heart failure patients with diabetes but not in those without diabetes

C Kistorp; AY Chong; F Gustafsson; S Galatius; I Raymond; J Faber; Gregory Lip; P Hildebrandt

doi:10.1016/j.ejheart.2008.02.012

Biomarkers of endothelial dysfunction are elevated and related to prognosis in chronic heart failure patients with diabetes but not in those without diabetes

C Kistorp, AY Chong, F Gustafsson, S Galatius, I Raymond, J Faber, Gregory Lip, P Hildebrandt

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Abstract

BACKGROUND: Biomarkers of endothelial dysfunction, such as soluble E-selectin, and von Willebrand factor (vWf) are elevated in patients with chronic heart failure (CHF). The impact of diabetes mellitus (DM) on these biomarkers, and their relation to prognosis remains unknown. AIMS: to investigate the impact of DM on plasma levels and the prognostic value of E-selectin and vWf in patients with CHF. METHODS AND RESULTS: Plasma levels of E-selectin and vWf were measured in 195 CHF patients with (n=48, 24.5%), and without DM, and in 116 age-matched healthy controls. Compared with controls, median plasma E-selectin levels were higher in CHF patients with DM (P=0.012), but not in CHF patients without DM (P=0.45); vWf levels were also higher in CHF patients with DM (P

Original language	English
Pages (from-to)	380-7
Number of pages	8
Journal	European Journal of Heart Failure
Volume	10
Issue number	4
DOIs	https://doi.org/10.1016/j.ejheart.2008.02.012
Publication status	Published - 1 Apr 2008

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10.1016/j.ejheart.2008.02.012

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title = "Biomarkers of endothelial dysfunction are elevated and related to prognosis in chronic heart failure patients with diabetes but not in those without diabetes",

abstract = "BACKGROUND: Biomarkers of endothelial dysfunction, such as soluble E-selectin, and von Willebrand factor (vWf) are elevated in patients with chronic heart failure (CHF). The impact of diabetes mellitus (DM) on these biomarkers, and their relation to prognosis remains unknown. AIMS: to investigate the impact of DM on plasma levels and the prognostic value of E-selectin and vWf in patients with CHF. METHODS AND RESULTS: Plasma levels of E-selectin and vWf were measured in 195 CHF patients with (n=48, 24.5%), and without DM, and in 116 age-matched healthy controls. Compared with controls, median plasma E-selectin levels were higher in CHF patients with DM (P=0.012), but not in CHF patients without DM (P=0.45); vWf levels were also higher in CHF patients with DM (P",

author = "C Kistorp and AY Chong and F Gustafsson and S Galatius and I Raymond and J Faber and Gregory Lip and P Hildebrandt",

year = "2008",

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day = "1",

doi = "10.1016/j.ejheart.2008.02.012",

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journal = "European Journal of Heart Failure",

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Kistorp, C, Chong, AY, Gustafsson, F, Galatius, S, Raymond, I, Faber, J, Lip, G & Hildebrandt, P 2008, 'Biomarkers of endothelial dysfunction are elevated and related to prognosis in chronic heart failure patients with diabetes but not in those without diabetes', European Journal of Heart Failure, vol. 10, no. 4, pp. 380-7. https://doi.org/10.1016/j.ejheart.2008.02.012

TY - JOUR

T1 - Biomarkers of endothelial dysfunction are elevated and related to prognosis in chronic heart failure patients with diabetes but not in those without diabetes

AU - Kistorp, C

AU - Chong, AY

AU - Gustafsson, F

AU - Galatius, S

AU - Raymond, I

AU - Faber, J

AU - Lip, Gregory

AU - Hildebrandt, P

PY - 2008/4/1

Y1 - 2008/4/1

N2 - BACKGROUND: Biomarkers of endothelial dysfunction, such as soluble E-selectin, and von Willebrand factor (vWf) are elevated in patients with chronic heart failure (CHF). The impact of diabetes mellitus (DM) on these biomarkers, and their relation to prognosis remains unknown. AIMS: to investigate the impact of DM on plasma levels and the prognostic value of E-selectin and vWf in patients with CHF. METHODS AND RESULTS: Plasma levels of E-selectin and vWf were measured in 195 CHF patients with (n=48, 24.5%), and without DM, and in 116 age-matched healthy controls. Compared with controls, median plasma E-selectin levels were higher in CHF patients with DM (P=0.012), but not in CHF patients without DM (P=0.45); vWf levels were also higher in CHF patients with DM (P

AB - BACKGROUND: Biomarkers of endothelial dysfunction, such as soluble E-selectin, and von Willebrand factor (vWf) are elevated in patients with chronic heart failure (CHF). The impact of diabetes mellitus (DM) on these biomarkers, and their relation to prognosis remains unknown. AIMS: to investigate the impact of DM on plasma levels and the prognostic value of E-selectin and vWf in patients with CHF. METHODS AND RESULTS: Plasma levels of E-selectin and vWf were measured in 195 CHF patients with (n=48, 24.5%), and without DM, and in 116 age-matched healthy controls. Compared with controls, median plasma E-selectin levels were higher in CHF patients with DM (P=0.012), but not in CHF patients without DM (P=0.45); vWf levels were also higher in CHF patients with DM (P

U2 - 10.1016/j.ejheart.2008.02.012

DO - 10.1016/j.ejheart.2008.02.012

M3 - Article

C2 - 18343722

SN - 1879-0844

VL - 10

SP - 380

EP - 387

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

IS - 4

ER -

Biomarkers of endothelial dysfunction are elevated and related to prognosis in chronic heart failure patients with diabetes but not in those without diabetes

Abstract

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