bif1, a new BMP signaling inhibitor, regulates embryonic hematopoiesis in the zebrafish.

Joey J. Ghersi, Christopher B. Mahony, Julien Y. Bertrand

Research output: Contribution to journalArticlepeer-review

105 Downloads (Pure)


Hematopoiesis maintains the entire blood system, and dysregulation of this process can lead to malignancies (leukemia), immunodeficiencies or red blood cell diseases (anemia, polycythemia vera). We took advantage of the zebrafish model that shares most of the genetic program involved in hematopoiesis with mammals to characterize a new gene of unknown function, si:ch73-299h12.2, which is expressed in the erythroid lineage during primitive, definitive and adult hematopoiesis. This gene, required during primitive and definitive erythropoiesis, encodes a C2H2 zinc-finger protein that inhibits BMP signaling. We therefore named this gene blood-inducing factor 1 and BMP inhibitory factor 1 ( bif1). We identified a bif1 ortholog in Sinocyclocheilus rhinocerous, another fish, and in the mouse genome. Both genes also inhibit BMP signaling when overexpressed in zebrafish. In conclusion, we have deorphanized a new zebrafish gene of unknown function: bif1 codes for a zinc-finger protein that inhibits BMP signaling and also regulates primitive erythropoiesis and definitive hematopoiesis.

Original languageEnglish
Article numberdev164103
Issue number6
Early online date5 Mar 2019
Publication statusPublished - 21 Mar 2019

Bibliographical note

© 2019. Published by The Company of Biologists Ltd.


  • BMP signalling
  • definitive hematopoiesis
  • erythropoiesis
  • hematopoietic stem cells
  • zebrafish
  • zinc finger proteins


Dive into the research topics of 'bif1, a new BMP signaling inhibitor, regulates embryonic hematopoiesis in the zebrafish.'. Together they form a unique fingerprint.

Cite this