Projects per year
Abstract
INTRODUCTION: Autoimmune hepatitis is a chronic immune-mediated liver injury, frequently associated with progression to end-stage liver disease if untreated. Patients commonly present with hepatitis, positive immune serology, elevated immunoglobulins and compatible liver histology, in the absence of an alternative aetiology.
SOURCES OF DATA: Data for this review were obtained using PubMed.
AREAS OF AGREEMENT: Disease usually responds to steroids and azathioprine, and appears to be a manifestation of autoimmune predisposition triggered in genetically susceptible individuals exposed to likely environmental challenges. We provide an up-to-date approach to disease understanding and management along with the clinical approach to diagnosis and current treatment suggestions.
AREAS OF CONTROVERSY: Controversies such as second line therapies and novel markers of disease activity are introduced.
GROWING POINTS: Increased understanding of the immunoregulatory mechanisms behind autoimmune hepatitis has led to opportunities for new therapies. These are developed including a discussion of timely research studies relevant to future therapies for patients.
Original language | English |
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Pages (from-to) | 181-91 |
Number of pages | 11 |
Journal | British Medical Bulletin |
Volume | 114 |
Issue number | 1 |
Early online date | 20 May 2015 |
DOIs | |
Publication status | Published - Jun 2015 |
Bibliographical note
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Dive into the research topics of 'Autoimmune hepatitis: an approach to disease understanding and management'. Together they form a unique fingerprint.Projects
- 1 Finished
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Intrahepatic Signals Involve in the Recruitment and Differentiation of IL-17 Secreting T Cells and Regulatory T Cells in Chronic Hepatitis - Fellowship
Oo, Y. (Principal Investigator)
4/01/12 → 5/01/18
Project: Research Councils